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首页> 外文期刊>Folia histochemica et cytobiologica >Expression of p130cas, E-cadherin and β-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis
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Expression of p130cas, E-cadherin and β-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis

机译：p130cas，E-钙粘蛋白和β-连环蛋白在非小细胞肺癌中的表达及其与临床病理参数的相关性：p130cas过表达预示不良预后

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p130cas (p130 Crk-associated substrate) is a scaffolding protein and plays an important role in regulating focal adhesion and driving cell migration. Also, the destruction of E-cadherin/β-catenin adhesive complex is one of the changes that characterizes the invasive phenotype of tumors . The aim of this study is to evaluate the role of p130cas, E-cadherin, and β-catenin expression in patients with non-small cell lung cancer (NSCLC). We examined the expression of p130cas, E-cadherin, and β-catenin in 105 lung cancer tissues and paired adjacent normal lung tissues using immunohistochemistry. The overexpression of p130cas was observed in 61.9% (65/105) of lung cancer samples. The overexpression of p130cas was correlated with abnormal expression of E-cadherin and β-catenin ( P =0.002 and P =0.006, respectively). Chi-square test showed that the overexpression of p130cas correlated positively with lymph node metastasis and high TNM stage. The Log-Rank test revealed that the mean survival time of patients with p130cas overexpression (36.31 ± 5.66 months) was markedly shorter than those with p130cas normal expression (60.57 ± 6.95 months). Multivariable analysis indicated p130cas overexpression ( P <0.001) as an independent significant prognostic factor for NSCLC patients’ survival. These results indicate that p130cas may impact a variety of clinicopathological features of NSCLC and may y influence the prognosis of lung cancer patients.
机译：p130cas（p130与Crk相关的底物）是一种支架蛋白，在调节粘着斑和驱动细胞迁移中起着重要作用。同样，破坏E-钙粘蛋白/β-连环蛋白粘附复合物是表征肿瘤的侵入表型的变化之一。这项研究的目的是评估p130cas，E-cadherin和β-catenin在非小细胞肺癌（NSCLC）患者中的表达。我们使用免疫组织化学方法检测了p130cas，E-cadherin和β-catenin在105份肺癌组织和配对的正常肺组织中的表达。在61.9％（65/105）的肺癌样本中观察到p130cas过表达。 p130cas的过表达与E-钙粘蛋白和β-连环蛋白的异常表达相关（分别为P = 0.002和P = 0.006）。卡方检验显示p130cas的过表达与淋巴结转移和高TNM分期呈正相关。 Log-Rank检验显示，p130cas过表达的患者（36.31±5.66个月）的平均生存时间明显短于p130cas正常表达的患者（60.57±6.95个月）。多变量分析表明p130cas过表达（P <0.001）是NSCLC患者生存的独立重要预后因素。这些结果表明，p130cas可能影响NSCLC的多种临床病理特征，并可能影响肺癌患者的预后。

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