Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017)

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Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017)

机译：审查对狗进行为期一年的剂量重复毒性试验以对农药（农药）进行毒理学评估（FSCJ农药专家委员会的决定，2017年12月21日）

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In the toxicological evaluation of pesticides (agricultural chemicals), their toxicities have been evaluated based on studies in rodents such as rats and mice as well as in non-rodents such as rabbits and dogs. Here, reflecting a research performed under the Food Safety Commission of Japan (FSCJ) grant on pesticide toxicity study~(1)), international trends and also scientific points of view, the necessity of chronic dog toxicity studies was reconsidered for the use in toxicological evaluation of pesticides.

机译：在对农药（农药）进行毒理学评估时，已基于对啮齿类动物（如大鼠和小鼠）以及非啮齿类动物（如兔和狗）的研究，评估了其毒性。在这里，反映了日本食品安全委员会（FSCJ）进行的关于农药毒性研究的研究〜（1），国际趋势以及科学观点，重新考虑了将慢性狗毒性研究用于毒理学的必要性。农药评估。

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《Food Safety》 |2018年第4期|共2页
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1. Evaluation of Necessity of 1-year Toxicity Study in Dogs - development of the New Tiered Approach for Toxicity Studies of Pesticide Considering Species Difference in “toxicity profile” and “toxicity dose-response” [J] . Atsushi Ono, Takahiro Yoshizawa, Kiyoshi Matsumoto Food Safety . 2018,第3期

机译：评估狗一年毒性研究的必要性-考虑“物种毒性”和“毒性剂量反应”物种差异的新型农药毒性研究分层方法的开发
2. A retrospective analysis of toxicity studies in dogs and impact on the chronic reference dose for conventional pesticide chemicals. [J] . Dellarco VL, Rowland J, May B Critical reviews in toxicology . 2010,第1期

机译：犬毒性研究的回顾性分析及其对常规农药化学物质慢性参考剂量的影响。
3. A retrospective analysis of toxicity studies in dogs and impact on the chronic reference dose for conventional pesticide chemicals. [J] . Dellarco VL, Rowland J, May B Critical reviews in toxicology . 2010,第1期

机译：犬毒性研究的回顾性分析及对常规农药化学品慢性参考剂量的影响。
4. Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide FSCJ 21 December 2017) [O] . Food Safety Commission of Japan 2018

机译：审查对狗进行的为期一年的重复剂量口服毒性研究以对农药（农药）进行毒理学评估（FSCJ农药专家委员会的决定2017年12月21日）
5. Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017) [O] . 2018

机译：审查农药毒理学评估的一年重复剂量口腔毒性研究（农业化学品）（农药专家委员会，FSCJ，2017年12月21日决定）
6. Results of a Repeated Dose 28-Day Toxicity Study in Dogs, Oral Administration, with an Experimental Pesticide. [R] . 2014

机译：狗，口服给药，实验性农药重复剂量28天毒性研究的结果。

Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017)

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