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首页> 外文期刊>Folia histochemica et cytobiologica >Proinflammatory chemokine gene expression influences survival of patients with non-Hodgkin’s lymphoma
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Proinflammatory chemokine gene expression influences survival of patients with non-Hodgkin’s lymphoma

机译：促炎性趋化因子基因表达影响非霍奇金淋巴瘤患者的生存

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The migration, survival and proliferation of cells is the basis for all physiologic and pathologic processes in the human body. All these reactions are regulated by a complex chemokine network that guides lymphocytes homing, chemotaxis, adhesion and interplay between immunologic system response cells. Chemokines are also responsible for metastatic dissemination of cancers, including Hodgkin’s and non-Hodgkin’s lymphomas. The purpose of this study was to determine chemokine gene expression (CXCL8, CXCL10, CCL2, CCL3, CCL4 and CCL5) in lymphoma lymph nodes compared to their expression in reactive lymph nodes. We also analyzed the influence of chemokine gene expression on the survival of lymphoma patients. Chemokine gene expression was evaluated in 37 lymphoma lymph nodes and in 25 samples of reactive lymph nodes. Gene expression of chemokines CXCL8, CXCL10, CCL2, CCL3, CCL4 and CCL5 was measured using the PCR method. Statistical analysis was performed using CSS Statistica for Windows (version 7.0) software. Probability values < < 0.05 were considered statistically significant and those between 0.05 and 0.1 as indicative of a trend. We found lower CXCL8 and CXCL10 gene expression in lymphoma lymph nodes compared to reactive lymph nodes. In the cases of CCL2 and CCL3, expression in lymphomas was higher than in reactive lymph nodes. Patients with high expression of CCL2 and CXCL10 had shorter survival. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 2, pp. 240–247)
机译：细胞的迁移，存活和增殖是人体所有生理和病理过程的基础。所有这些反应均由复杂的趋化因子网络调节，该趋化因子网络可指导淋巴细胞归巢，趋化性，免疫系统反应细胞之间的粘附和相互作用。趋化因子还负责癌症的转移性传播，包括霍奇金淋巴瘤和非霍奇金淋巴瘤。这项研究的目的是确定淋巴瘤淋巴结中的趋化因子基因表达（CXCL8，CXCL10，CCL2，CCL3，CCL4和CCL5）与其在活性淋巴结中的表达相比。我们还分析了趋化因子基因表达对淋巴瘤患者生存的影响。在37个淋巴瘤淋巴结和25个反应性淋巴结样品中评估趋化因子基因表达。使用PCR方法测量趋化因子CXCL8，CXCL10，CCL2，CCL3，CCL4和CCL5的基因表达。使用Windows的CSS Statistica（7.0版）软件进行统计分析。概率值0.05被认为具有统计学意义，而0.05到0.1之间的概率值表示趋势。我们发现与反应性淋巴结相比，淋巴瘤淋巴结中的CXCL8和CXCL10基因表达较低。在CCL2和CCL3的情况下，淋巴瘤的表达高于反应性淋巴结。 CCL2和CXCL10高表达的患者生存期较短。 （Folia Histochemica et Cytobiologica 2011;第49卷，第2期，第240-247页）

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