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首页> 外文期刊>Folia histochemica et cytobiologica >Inflammatory bowel disease — is there something new in the immunological background?
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Inflammatory bowel disease — is there something new in the immunological background?

机译：炎性肠病-免疫学背景是否有新变化？

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In the present paper we correlate clinical data, as well as histopathological, immunohistochemical and molecular biology methods, with the occurrence of both forms of inflammatory bowel disease (IBD) i.e. ulcerative colitis and Crohn’s disease. We found that patients with a history of Epstein-Barr virus (EBV) or cytomegalovirus (CMV) infections, as well as steroid treatment, had increased susceptibility to the development of IBD. The diagnosis of IBD was confirmed by histopathology. Previous infections by EBV and CMV, as well as M. tuberculosis, were proved by PCR-based techniques and in situ hybridization. We found PCR-proved latent viral infections in 30–50% of the IBD patients we studied. However, we were unable to prove the presence of viral antigens by immunohistochemistry for EBV or CMV. We found positive correlations between the presence of anti-CMV IgG, as well as PCR-positive results for M. tuberculosis with an ulcerative colitis diagnosis. Additionally, up to 80% of IBD patients used steroids, which was found to be correlated with a diagnosis of Crohn’s disease. Our data may support the theory that IBD could be related to previous viral infections and the use of steroids. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 2, 357–362)
机译：在本文中，我们将临床数据以及组织病理学，免疫组织化学和分子生物学方法与两种形式的炎症性肠病（IBD），即溃疡性结肠炎和克罗恩病的发生联系起来。我们发现具有爱泼斯坦-巴尔病毒（EBV）或巨细胞病毒（CMV）感染史以及类固醇治疗的患者对IBD发生的敏感性增加。组织病理学证实了IBD的诊断。通过基于PCR的技术和原位杂交证明了先前由EBV和CMV以及结核分枝杆菌感染。我们在我们研究的30–50％的IBD患者中发现了PCR证实的潜伏病毒感染。但是，我们无法通过EBV或CMV的免疫组织化学方法证明病毒抗原的存在。我们发现抗CMV IgG的存在与结核分枝杆菌与溃疡性结肠炎诊断的PCR阳性结果之间呈正相关。另外，多达80％的IBD患者使用了类固醇，这被发现与克罗恩病的诊断有关。我们的数据可能支持IBD可能与以前的病毒感染和类固醇使用有关的理论。 （Folia Histochemica et Cytobiologica 2011，Vol.49，No.2，357-362）

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