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首页> 外文期刊>Filaria journal >The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts
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The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts

机译：与原发感染宿主相比，接种疫苗的宿主中丝状感染幼虫的皮下运动受到损害

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Our aim in this study was to observe the movements of filarial infective larvae following inoculation into the mammalian host and to assess the effect of vaccination on larval migration, in situ. Here we present recordings of larvae progressing through the subcutaneous tissues and inguinal lymph node of primary infected or vaccinated mice. We used the filaria Litomosoides sigmodontis in BALB/c mice that were necropsied 6 hours after the challenge inoculation of 200 larvae. Subcutaneous tissue sections were taken from the inoculation site and larvae were filmed in order to quantify their movements. Our analyses showed that the subcutaneous larvae were less motile in the vaccinated mice than in primary-infected mice and had more leucocytes attached to the cuticle. We propose that this reduced motility may result in the failure of a majority of larvae to evade the inflammatory reaction, thereby being a possible mechanism involved in the early vaccine-induced protection.
机译：我们在这项研究中的目的是观察接种到哺乳动物宿主后丝虫感染性幼虫的运动，并评估疫苗接种对幼虫迁移的影响。在这里，我们介绍了通过初级感染或接种的小鼠的皮下组织和腹股沟淋巴结进行的幼虫记录。我们在BALB / c小鼠中使用了丝状体Litomosoides sigmodontis，在对200只幼虫进行攻击接种后6个小时进行了尸检。从接种部位取出皮下组织切片，并拍摄幼虫以定量其运动。我们的分析表明，与初次感染的小鼠相比，接种疫苗的小鼠的皮下幼虫运动能力较弱，并且有更多的白细胞附着在角质层上。我们提出，这种运动力降低可能导致大多数幼虫无法逃避炎症反应，从而成为早期疫苗诱导的保护的可能机制。

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