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首页> 外文期刊>Fisheries and Aquatic Sciences >Quinone Reductase Induction Activity of Phlorotannins Derived from Eisenia bicyclis in Hepa1c1c7 Cells
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Quinone Reductase Induction Activity of Phlorotannins Derived from Eisenia bicyclis in Hepa1c1c7 Cells

机译：环孢单胞菌来源的环磷酰胺在Hepa1c1c7细胞中的醌还原酶诱导活性。

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摘要

To assess the feasibility of phlorotannins from Eisenia bicyclis as cancer chemopreventative agents, we tested whether they induced quinone reductase (QR) in Hepa1c1c7 cells. The ethyl acetate (EtOAc) soluble fraction obtained from E. bicyclis exhibited a QR induction activity in Hepa1c1c7 cells. Successive column chromatography of the active EtOAc fraction resulted in the isolation of four phlorotannins. Their structures were elucidated using one- and two-dimensional nuclear magnetic resonance spectroscopic techniques and characterized as phloroglucinol (1), dioxinodehydroeckol (2), dieckol (3), and fucofuroeckol-A (4). Among these compounds, fucofuroeckol-A (4) showed moderate QR induction activity, and dioxinodehydroeckol (2) exhibited potent QR induction potency with fold induction at a concentration of compared to the dimethyl sulfoxide solvent-treated control cells. However, phloroglucinol (1) and dieckol (3) exerted no detectable QR induction activity in Hepa1c1c7 cells. These results suggest that dioxinodehydroeckol could serve as a useful cancer chemopreventive chemical.
机译：为了评估来自Eisenia bicyclis的phlorotannins作为癌症化学预防剂的可行性，我们测试了它们是否在Hepa1c1c7细胞中诱导了醌还原酶（QR）。从双歧杆菌获得的乙酸乙酯（EtOAc）可溶级分在Hepa1c1c7细胞中表现出QR诱导活性。活性EtOAc馏分的连续柱色谱法导致分离出四个邻苯二酚单宁。使用一维和二维核磁共振波谱技术阐明了它们的结构，并将其表征为间苯三酚（1），二氧萘并二氢萘酚（2），二eckol（3）和fucofuroeckol-A（4）。在这些化合物中，岩藻酰氟甲酚A（4）显示中等的QR诱导活性，与二甲亚砜溶剂处理的对照细胞相比，二氧呋喃二氢萘酚（2）表现出强的QR诱导效力和倍数诱导诱导。然而，间苯三酚（1）和地eckol（3）在Hepa1c1c7细胞中没有检测到QR诱导活性。这些结果表明，二氧杂环丁烯二酚可作为一种有用的癌症化学预防药。

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