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首页> 外文期刊>Fisheries and Aquatic Sciences >Reponses of the Hepatic Microsomal Cytochrome P450 Monooxygenase System in Rock Bream Oplegnathus fasciatus Exposed to Tributyltin (TBT)
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Reponses of the Hepatic Microsomal Cytochrome P450 Monooxygenase System in Rock Bream Oplegnathus fasciatus Exposed to Tributyltin (TBT)

机译：暴露于三丁基锡（TBT）的岩鲷Oplegnathus fasciatus中肝微粒体细胞色素P450单加氧酶系统的反应。

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摘要

The study was conducted to investigate the responses of the hepatic microsomal cytochrome P450 monooxygenase system in the rock bream Oplegnathus fasciatus after chronic exposure to 0, 1, 2, 4, and tributyltin (TBT) concentrations for 4 weeks. Hepatic cytochrome 450 content and ethoxyresorufin O-deethylation (EROD) activity were found to significantly increase in fish treated with the higher concentration of TBT ( ); however, no significant changes were observed in penthoxyresorufin O-deethylation (PROD) activity in all treated groups compared to the control group. These findings suggest that exposure to a low TBT concentration ( ) has the potential to induce cytochrome 450 content and EROD enzyme activity in hepatic tissue in the rock bream.
机译：进行这项研究的目的是研究长期暴露于0、1、2、4和三丁基锡（TBT）浓度4周后，岩鲷Oplegnathus fasciatus中肝微粒体细胞色素P450单加氧酶系统的反应。发现在较高浓度的TBT处理下的鱼肝细胞色素450含量和乙氧基异色蛋白O-去乙基化（EROD）活性显着增加。然而，与对照组相比，所有治疗组的戊氧基间苯二酚O-脱乙基（PROD）活性均未观察到显着变化。这些发现表明，暴露于低TBT浓度（）可能会诱导鲷鱼肝组织中细胞色素450含量和EROD酶活性。

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