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首页> 外文期刊>Frontiers in Endocrinology >Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes
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Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes

机译：ACTH信号传导对类固醇基因转录调控的影响

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The trophic peptide hormone adrenocorticotropic (ACTH) stimulates steroid hormone biosynthesis evoking both a rapid, acute response and a long-term, chronic response, via the activation of cAMP/protein kinase A (PKA) signaling. The acute response is initiated by the mobilization of cholesterol from lipid stores and its delivery to the inner mitochondrial membrane, a process that is mediated by the steroidogenic acute regulatory protein. The chronic response results in the increased coordinated transcription of genes encoding steroidogenic enzymes. ACTH binding to its cognate receptor, melanocortin 2 receptor (MC2R), stimulates adenylyl cyclase, thus inducing cAMP production, PKA activation, and phosphorylation of specific nuclear factors, which bind to target promoters and facilitate coactivator protein recruitment to direct steroidogenic gene transcription. This review provides a general view of the transcriptional control exerted by the ACTH/cAMP system on the expression of genes encoding for steroidogenic enzymes in the adrenal cortex. Special emphasis will be given to the transcription factors required to mediate ACTH-dependent transcription of steroidogenic genes.
机译：营养肽激素促肾上腺皮质激素（ACTH）通过激活cAMP /蛋白激酶A（PKA）信号传导刺激类固醇激素的生物合成，引起快速，急性反应和长期，长期反应。急性反应是由胆固醇从脂质存储中动员并传递到线粒体内膜而引发的，该过程由类固醇生成的急性调节蛋白介导。慢性反应导致编码类固醇生成酶的基因协调转录增加。 ACTH与其同源受体melanocortin 2受体（MC2R）结合，刺激腺苷酸环化酶，从而诱导cAMP产生，PKA激活和特定核因子的磷酸化，这些因子与靶标启动子结合并促进共激活蛋白募集以指导类固醇生成基因转录。这篇综述提供了ACTH / cAMP系统对肾上腺皮质中类固醇生成酶编码基因表达的转录控制的总体看法。将特别强调介导类固醇生成基因的ACTH依赖性转录所需的转录因子。

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