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首页> 外文期刊>Frontiers in Endocrinology >Effects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-γ and Behavior
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Effects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-γ and Behavior

机译：慢性社会应激和孕妇鼻内催产素和加压素对后代γ-干扰素和行为的影响

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Recent studies support the hypothesis that the adverse effects of early-life adversity and transgenerational stress on neural plasticity and behavior are mediated by inflammation. The objective of the present study was to investigate the immune and behavioral programing effects of intranasal (IN) vasopressin (AVP) and oxytocin (OXT) treatment of chronic social stress (CSS)-exposed F1 dams on F2 juvenile female offspring. It was hypothesized that maternal AVP and OXT treatment would have preventative effects on social stress-induced deficits in offspring anxiety and social behavior and that these effects would be associated with changes in interferon-γ (IFNγ). Control and CSS-exposed F1 dams were administered IN saline, AVP, or OXT during lactation and the F2 juvenile female offspring were assessed for basal plasma IFNγ and perseverative, anxiety, and social behavior. CSS F2 female juvenile offspring had elevated IFNγ levels and exhibited increased repetitive/perseverative and anxiety behaviors and deficits in social behavior. These effects were modulated by AVP and OXT in a context- and behavior-dependent manner, with OXT exhibiting preventative effects on repetitive and anxiety behaviors and AVP possessing preventative effects on social behavior deficits and anxiety. Basal IFNγ levels were elevated in the F2 offspring of OXT-treated F1 dams, but IFNγ was not correlated with the behavioral effects. These results support the hypothesis that maternal AVP and OXT treatment have context- and behavior-specific effects on peripheral IFNγ levels and perseverative, anxiety, and social behaviors in the female offspring of early-life social stress-exposed dams. Both maternal AVP and OXT are effective at preventing social stress-induced increases in self-directed measures of anxiety, and AVP is particularly effective at preventing impairments in overall social contact. OXT is specifically effective at preventing repetitive/perseverative behaviors, yet is ineffective at preventing deficits in overall social behavior.
机译：最近的研究支持以下假设：炎症会介导早期逆境和跨代应激对神经可塑性和行为的不利影响。本研究的目的是调查鼻内（IN）加压素（AVP）和催产素（OXT）处理暴露于慢性社会压力（CSS）的F1大坝对F2幼龄雌性后代的免疫和行为编程作用。据推测，孕妇AVP和OXT治疗将对后代焦虑和社交行为中的社会压力引起的缺陷具有预防作用，并且这些作用将与γ-干扰素（IFNγ）的改变有关。在哺乳期间，对照组和CSS暴露的F1大坝在生理盐水，AVP或OXT中施用，并评估了F2幼龄雌性后代的基础血浆IFNγ以及持久性，焦虑性和社交行为。 CSS F2雌性少年后代具有较高的IFNγ水平，并表现出重复/持续性和焦虑行为增加以及社交行为缺陷。这些效应由AVP和OXT以与上下文和行为有关的方式进行调节，其中OXT对重复性和焦虑行为具有预防作用，而AVP对社交行为缺陷和焦虑具有预防作用。 OXT处理的F1大坝的F2子代的基础IFNγ水平升高，但IFNγ与行为影响无关。这些结果支持这样的假说，即母亲AVP和OXT治疗对早期社会压力暴露水坝的雌性后代的外周IFNγ水平以及持久性，焦虑性和社交行为具有背景和行为特异性影响。产妇AVP和OXT均可有效预防社交压力引起的焦虑症自我指导性测验的增加，而AVP尤其可有效预防整体社交接触的障碍。 OXT在预防重复性/持久性行为方面特别有效，但在预防整体社会行为上的缺陷方面却无效。

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