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首页> 外文期刊>Frontiers in Endocrinology >The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry
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The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry

机译：大发酸信号在秀丽隐杆线虫的发育和寿命中的作用：使用前沿分析化学方法更深入地研究

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Steroid hormones regulate physiological processes in species ranging from plants to humans. A wide range of steroid hormones exist, and their contributions to processes, such as growth, reproduction, development, and aging, is almost always complex. Understanding the biosynthetic pathways that generate steroid hormones and the signaling pathways that mediate their effects is thus of fundamental importance. In this work, we review recent advances in (i) the biological role of steroid hormones in the roundworm Caenorhabditis elegans and (ii) the development of novel methods to facilitate the detection and identification of these molecules. Our current understanding of steroid signaling in this simple organism serves to illustrate the challenges we face moving forward. First, it seems clear that we have not yet identified all of the enzymes responsible for steroid biosynthesis and/or degradation. Second, perturbation of steroid signaling affects a wide range of phenotypes, and subtly different steroid molecules can have distinct effects. Finally, steroid hormone levels are critically important, and minute variations in quantity can profoundly impact a phenotype. Thus, it is imperative that we develop innovative analytical tools and combine them with cutting-edge approaches including comprehensive and highly selective liquid chromatography coupled to mass spectrometry based on new methods such as supercritical fluid chromatography coupled to mass spectrometry (SFC-MS) if we are to obtain a better understanding of the biological functions of steroid signaling.
机译：类固醇激素调节从植物到人类的物种的生理过程。存在大量的类固醇激素，它们对生长，繁殖，发育和衰老等过程的贡献几乎总是很复杂。因此，了解产生类固醇激素的生物合成途径和介导其作用的信号传导途径至关重要。在这项工作中，我们回顾了（i）the虫类秀丽隐杆线虫中类固醇激素的生物学作用和（ii）促进检测和鉴定这些分子的新方法的最新进展。我们目前对这种简单生物中类固醇信号传导的理解有助于说明我们所面临的挑战。首先，似乎很清楚，我们尚未鉴定出负责类固醇生物合成和/或降解的所有酶。其次，类固醇信号传导的扰动会影响广泛的表型，并且细微不同的类固醇分子可能具有不同的作用。最后，类固醇激素水平至关重要，数量的微小变化会深刻影响表型。因此，我们有必要开发创新的分析工具，并将其与最先进的方法相结合，包括基于新方法（例如超临界流体色谱-质谱联用（SFC-MS））的综合和高选择性液相色谱-质谱联用的新方法。以便更好地了解类固醇信号传导的生物学功能。

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