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首页> 外文期刊>Frontiers in Endocrinology >Preliminary Findings Show Maternal Hypothyroidism May Contribute to Abnormal Cortical Morphology in Offspring
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Preliminary Findings Show Maternal Hypothyroidism May Contribute to Abnormal Cortical Morphology in Offspring

机译：初步发现表明，母亲甲状腺功能减退可能会导致后代的皮质形态异常

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In rodents, insufficient thyroid hormone (TH) gestationally has adverse effects on cerebral cortex development. Comparable studies of humans examining how TH insufficiency affects cortical morphology are limited to children with congenital hypothyroidism or offspring of hypothyroxinemic women; effects on cortex of children born to women with clinically diagnosed hypothyroidism are not known. We studied archived MRI scans from 22 children aged 10–12?years born to women treated for preexisting or de novo hypothyroidism in pregnancy (HYPO) and 24 similar age and sex controls from euthyroid women. FreeSurfer Image Analysis Suite software was used to measure cortical thickness (CT) and a vertex-based approach served to compare HYPO versus control groups and Severe versus Mild HYPO subgroups as well as to perform regression analyses examining effects of trimester-specific maternal TSH on CT. Results showed that relative to controls, HYPO had multiple regions of both cortical thinning and thickening, which differed for left and right hemispheres. In HYPO, thinning was confined to medial and mid-lateral regions of each hemisphere and thickening to superior regions (primarily frontal) of the left hemisphere and inferior regions (particularly occipital and temporal) of the right. The Severe HYPO subgroup showed more thinning than Mild in frontal and temporal regions and more thickening in bilateral posterior and frontal regions. Maternal TSH values predicted degree of thinning and thickening within multiple brain regions, with the pattern and direction of correlations differing by trimester. Notably, some correlations remained when cases born to women with severe hypothyroidism were removed from the analyses, suggesting that mild variations of maternal TH may permanently affect offspring cortex. We conclude that maternal hypothyroidism during pregnancy has long-lasting manifestations on the cortical morphology of their offspring with specific effects reflecting both severity and timing of maternal TH insufficiency.
机译：在啮齿动物中，妊娠期甲状腺激素（TH）不足会对大脑皮层发育产生不利影响。进行人类研究，研究TH不足如何影响皮层形态的研究仅限于先天性甲状腺功能低下或甲状腺功能低下妇女的后代。尚无临床诊断为甲状腺功能减退症的妇女对儿童所生孩子的皮层影响。我们研究了22例10-12岁儿童的存档MRI扫描结果，这些儿童是因妊娠（HYPO）既往存在或从头甲状腺功能减退症而接受治疗的妇女所生，而24例年龄和性别相仿的甲状腺癌妇女也是如此。 FreeSurfer Image Analysis Suite软件用于测量皮层厚度（CT），基于顶点的方法可用于比较HYPO与对照组，重度HYPO与轻度HYPO亚组，并进行回归分析，以检查孕中期特定母体TSH对CT的影响。结果显示，相对于对照，HYPO具有多个皮质变薄和增厚区域，左右半球有所不同。在HYPO中，变薄仅限于每个半球的内侧和中外侧区域，而加厚则限于左半球的上方区域（主要是额叶）和右侧的下部区域（尤其是枕骨和颞骨）。严重的HYPO亚组在额叶和颞叶区域的变薄程度比Mild薄，在双边的后部和额叶区域变厚。孕妇的TSH值可预测多个大脑区域内变薄和增厚的程度，相关模式和方向因孕中期而异。值得注意的是，当从分析中删除患有严重甲状腺功能低下的女性所生的病例时，仍存在某些相关性，这表明母亲TH的轻度变化可能会永久影响后代皮层。我们得出的结论是，孕期母亲甲状腺功能减退症在其后代的皮质形态上具有持久的表现，其特定作用反映了母亲TH功能不全的严重程度和时间。

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