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Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD

机译：FGF21的调控，生理功能及其与NAFLD的关系的研究视角

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Fibroblast growth factor 21 (FGF21) is a metabolic hormone primarily secreted from the liver and functions in multiple tissues. Various transcription factors induce FGF21 expression in the liver, which indicates that FGF21 is a mediator of multiple environmental cues. FGF21 alters metabolism under starvation conditions, protects the body from energy depletion, and extends life span. Pharmacological administration of FGF21 alleviates dyslipidemia and induces weight loss in obese animals. In addition to the well-studied functions of FG21, several lines of recent evidence indicate a possible link between FGF21 and non-alcoholic fatty liver disease (NAFLD). High serum levels of FGF21 are associated with NAFLD and its risk factors, such as endoplasmic reticulum stress and chronic inflammation. In addition, FGF21 alleviates the major risk factors of NAFLD, including obesity, dyslipidemia, and insulin insensitivity. Thus, FGF21 is a potential drug candidate for diseases, such as NAFLD, dyslipidemia, and type 2 diabetes. In this review, the research perspectives of FGF21 and therapeutic potencies of FGF21 as a modulator of NAFLD are summarized.
机译：成纤维细胞生长因子21（FGF21）是一种主要从肝脏分泌的代谢激素，在多种组织中起作用。多种转录因子诱导肝脏中FGF21的表达，这表明FGF21是多种环境提示的介体。 FGF21在饥饿状态下会改变新陈代谢，保护人体免受能量消耗，并延长寿命。 FGF21的药理管理可减轻血脂异常，并减轻肥胖动物的体重。除了对FG21的功能进行了深入研究外，最近的一些证据还表明FGF21与非酒精性脂肪肝疾病（NAFLD）之间可能存在联系。 FGF21的高血清水平与NAFLD及其危险因素有关，例如内质网应激和慢性炎症。此外，FGF21减轻了NAFLD的主要危险因素，包括肥胖，血脂异常和胰岛素敏感性不足。因此，FGF21是潜在的疾病候选药物，例如NAFLD，血脂异常和2型糖尿病。在这篇综述中，总结了FGF21的研究前景和作为NAFLD调节剂的FGF21的治疗效力。

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