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New frontier in glycoprotein hormones and their receptors structure–function

机译：糖蛋白激素及其受体结构-功能的新领域

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Last two decades of structure–function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed based on experimental data in the past stood the test of time and have been, at least in part, confirmed and/or remained compatible with the new structures resolved at the atomic level. Major advances in understanding of the ligand–receptor relationships are heralding the dawn of a new era for GPHs and their receptors, although many basic questions still remain unanswered. This article examines retrospectively several basic science aspects of GPH super-agonists and related “biosuperiors” in a broader context of the advances in the ligand–receptor structure–function relationships and new mechanistic models generated based on the structure elucidation. Due to selective focus of my comments and perspectives in certain parts, the reader is directed to the most relevant publications and reviews in the field for more comprehensive analyses.
机译：最近几十年来，在许多实验室进行的结构-功能研究为理解糖蛋白激素（GPH）及其关联受体的基础科学，生理学，病理生理学，药理学和比较方面提供了实质性进展。过去基于实验数据开发的多种概念和模型经受了时间的考验，并且至少部分地得到了确认和/或保持与在原子级解析的新结构兼容。尽管许多基本问题仍未得到解答，但对配体-受体关系的理解的重大进步预示着GPH及其受体新时代的到来。本文回顾了GPH超级激动剂和相关“生物超级”的几个基础科学方面，以更广泛的背景探讨配体-受体结构-功能关系的发展以及基于结构阐明产生的新机制模型。由于我对某些部分的评论和观点的选择性关注，读者将被带往该领域最相关的出版物和评论，以进行更全面的分析。

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