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首页> 外文期刊>Frontiers in Endocrinology >Effects of a Macro-Nutrient Preload on Type 2 Diabetic Patients
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Effects of a Macro-Nutrient Preload on Type 2 Diabetic Patients

机译：大量营养预负荷对2型糖尿病患者的影响

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Aims Macro-nutrient preloads given 30?min before regular meals may improve metabolism. The aim was to investigate how type 2 diabetic patients react to a preload consisting of a blend of macro-nutrients with a low-glycemic index (Inzone Preload~(?)). Methods In a before–after study design, 30 subjects with type 2 diabetes mellitus (T2DM) were enrolled in a 12-week program. All subjects were given Inzone Preload (43% proteins, 29% carbohydrates, 10% lipids, and 9% fibers, 71?kcal), 30?min before each meal during 12?weeks. Fasting glucose and postprandial 2?h glucose were monitored every second week. Body weight (BW) and waist circumference were measured each month. Fasting plasma glucose, glycosylated hemoglobin, serum lipids, fasting insulin, C-reactive protein, and homeostasis model assessment were evaluated before and after the intervention. Subjective appetite was monitored using visual analogue scales after the Inzone Preload. Results The dietary intervention significantly influenced several metabolic parameters compared to base line. Inzone Preload treatment reduced mean postprandial plasma glucose levels (12.2?±?1.2 vs. 10.5?±?2.0?mmol/L), HbA1c (7.4?±?0.3 vs. 7.1?±?0.2%), mean total cholesterol (4.8?±?0.9 vs. 4.3?±?0.8?mmol/L), low-density lipoprotein cholesterol (2.8?±?0.6 vs. 2.5?±?0.4?mmol/L), and CRP (1.5?±?1.4 vs. 0.7?±?0.7?mg/L). BW loss of more than 3% was seen in 13 participants (43%). Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast ( p ?
机译：目的定期进餐前30分钟给予宏观营养素预负荷，以改善新陈代谢。目的是研究2型糖尿病患者对预负荷的反应，该预负荷由低血糖指数的大量营养素混合而成（Inzone Preload〜（？））。方法在一项前后研究设计中，将30名2型糖尿病（T2DM）受试者纳入为期12周的计划。在12周内，每餐前30分钟给所有受试者都提供Inzone Preload（43％蛋白质，29％碳水化合物，10％脂质和9％纤维，71卡路里）。每隔第二周监测空腹血糖和餐后2 h血糖。每月测量体重（BW）和腰围。在干预前后评估空腹血糖，糖基化血红蛋白，血清脂质，空腹胰岛素，C反应蛋白和体内稳态模型评估。 Inzone Preload后，使用视觉模拟量表监测主观食欲。结果与基线相比，饮食干预显着影响了几个代谢参数。 Inzone Preload治疗降低了餐后平均血糖水平（12.2±±1.2 vs. 10.5±±2.02.0mmol / L），HbA1c（7.4±±0.3和7.1±0.2％），平均总胆固醇（4.8低密度脂蛋白胆固醇（2.8±±0.6）vs. 2.5±±0.4±mmol / L）（4.3±±0.8）mmol / L）和CRP（1.5±±1.4） 0.7≤±≤0.7μmg/ L）。 13名参与者（43％）的体重损失超过3％。 Inzone Preload后的饱腹感明显高于惯常早餐后（p <0.05）。空腹血糖，高密度脂蛋白和总三酰甘油，HOMA-IR和HOMA-β均未见明显变化。结论大量营养素预负荷治疗可降低T2DM患者的餐后血糖，炎症标志物和血脂。大约一半的研究组的体重减轻。

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