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Insulin, Aging, and the Brain: Mechanisms and Implications

机译:胰岛素,衰老和大脑:机理和意义

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There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. However, the relevance of these to aging and longevity remains to be elucidated. Here, we review advances in our understanding of the physiological role of insulin in the brain, how insulin gets into the brain, and its relevance to aging and longevity. Furthermore, we examine possible future therapeutic applications and implications of insulin in the context of available models of delayed and accelerated aging.
机译:现在有大量令人印象深刻的文献涉及成功的衰老和长寿的胰岛素和胰岛素信号传导。来自有关胰岛素和胰岛素受体的体内和体外研究的新信息扩展了我们对胰岛素在脑中的生理作用的理解。但是,这些与衰老和寿命的相关性尚待阐明。在这里,我们回顾了对胰岛素在大脑中的生理作用,胰岛素如何进入大脑及其与衰老和长寿的相关性的理解方面的进展。此外,我们在延迟和加速衰老的可用模型的背景下,研究了胰岛素未来可能的治疗应用和意义。

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