• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Endocrinology >Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation
【24h】

Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation

机译：IGF1R在乳腺癌亚型，干性和谱系分化中的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Insulin-like growth factor (IGF) signaling is fundamental for growth and survival. A large body of evidence (laboratory, epidemiological, and clinical) implicates the exploitation of this pathway in cancer. Up to 50% of breast tumors express the activated form of the type 1 insulin-like growth factor receptor (IGF1R). Breast cancers are categorized into subtypes based upon hormone and ERRB2 receptor expression and/or gene expression profiling. Even though IGF1R influences tumorigenic phenotypes and drug resistance across all breast cancer subtypes, it has specific expression and function in each. In some subtypes, IGF1R levels correlate with a favorable prognosis, while in others it is associated with recurrence and poor prognosis, suggesting different actions based upon cellular and molecular contexts. In this review, we examine IGF1R expression and function as it relates to breast cancer subtype and therapy-acquired resistance. Additionally, we discuss the role of IGF1R in stem cell maintenance and lineage differentiation and how these cell fate influences may alter the differentiation potential and cellular composition of breast tumors.
机译：胰岛素样生长因子（IGF）信号对于生长和存活至关重要。大量证据（实验室，流行病学和临床）暗示了该途径在癌症中的应用。多达50％的乳腺肿瘤表达1型胰岛素样生长因子受体（IGF1R）的活化形式。根据激素和ERRB2受体的表达和/或基因表达谱，乳腺癌可分为亚型。即使IGF1R影响所有乳腺癌亚型的致癌表型和耐药性，它在每种乳腺癌中仍具有特定的表达和功能。在某些亚型中，IGF1R水平与预后良好相关，而在另一些亚型中，IGF1R水平与复发和预后不良相关，表明基于细胞和分子环境的不同作用。在这篇综述中，我们检查了IGF1R的表达和功能，因为它与乳腺癌亚型和治疗获得性耐药有关。此外，我们讨论了IGF1R在干细胞维持和谱系分化中的作用，以及这些细胞命运的影响如何改变乳腺肿瘤的分化潜能和细胞组成。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号