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首页> 外文期刊>Frontiers in Microbiology >The Probiotic Combination of Bifidobacterium longum subsp. infantis CECT 7210 and Bifidobacterium animalis subsp. lactis BPL6 Reduces Pathogen Loads and Improves Gut Health of Weaned Piglets Orally Challenged with Salmonella Typhimurium
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The Probiotic Combination of Bifidobacterium longum subsp. infantis CECT 7210 and Bifidobacterium animalis subsp. lactis BPL6 Reduces Pathogen Loads and Improves Gut Health of Weaned Piglets Orally Challenged with Salmonella Typhimurium

机译：长双歧杆菌亚种的益生菌组合。 infantis CECT 7210和 Bifidobacterium animalis subsp。 lactis BPL6减少了经沙门氏菌鼠伤寒口服的断奶仔猪的病原体负荷并改善了肠道健康

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Probiotics have been demonstrated to be useful to enhance gut health and prevent gastrointestinal infections in humans. Additionally, some multi-strain probiotic combinations have been suggested to have greater efficacy than single strains. The objective of this study is to demonstrate the potential of a combination of the probiotic strains: Bifidobacterium longum subsp. infantis CECT 7210 (brand name B. infantis IM1~(?)) and B. animalis subsp. lactis BPL6 to enhance gut health and to ameliorate the outcome of a Salmonella challenge using a weaning piglet model. Seventy-two 28-day-old weanling piglets, 7.7 (±0.28) kg of body-weight, were distributed in a 2 × 2 factorial design; treated or not with the probiotic combination and challenged or not with the pathogen. Animals were orally challenged after an adaptation period (Day 8) with a single dose (5 × 10~(8)cfu) of Salmonella Typhimurium. One animal per pen was euthanized on Day 12 (Day 4 post-inoculation [PI]) and Day 16 (Day 8 PI). All parameters responded to the challenge and 4 deaths were registered, indicating a severe but self-limiting challenge. Improvements registered in the challenged animals due to the probiotic were: increased voluntary feed-intake ( P probiotic × challenge = 0.078), reduced fecal excretion of Salmonella ( P = 0.028 at Day 1 PI and P < 0.10 at Days 3 and 5 PI), decreased rectal temperature ( P probiotic × day = 0.048) and improvements in the villous:crypt ratio ( P probiotic × challenge < 0.001). Moreover, general probiotic benefits were observed in both challenged and non-challenged groups: decreased diarrhea scores of the PI period ( P = 0.014), improved fermentation profiles on Day 8 PI (increased ileal acetic acid [ P = 0.008] and a tendency to lower colonic ammonia concentrations [ P = 0.078]), stimulation of intestinal immune response by increasing villous intraepithelial lymphocytes ( P = 0.015 on Day 8 PI) and an improved villous:crypt ratio ( P = 0.011). In conclusion, the multi-strain probiotic had a positive effect on reducing pathogen loads and alleviating animals in a Salmonella challenge. In addition, enhanced gut health and immunity was recorded in all animals receiving the probiotic, indicating an improvement in the post-weaning outcome.
机译：益生菌已被证明可用于增强肠道健康并预防人类的胃肠道感染。另外，已经提出一些多菌株益生菌组合比单一菌株具有更大的功效。这项研究的目的是证明益生菌菌株：长双歧杆菌亚种的组合的潜力。婴儿CECT 7210（商品名为婴儿B. IM1〜（？））和动物B.亚种。乳酸BPL6可使用断奶仔猪模型增强肠道健康并改善沙门氏菌攻击的结果。以2×2因子设计分配了72只28天大的断奶仔猪，体重为7.7（±0.28）kg。益生菌联合治疗与否，病原体挑战与否。在适应期（第8天）后，以单剂量（5×10〜（8）cfu）鼠伤寒沙门氏菌对动物进行口服攻击。在第12天（接种后第4天[PI]）和第16天（第8天PI）将每只钢笔安乐死。所有参数均对挑战作出反应，并记录了4例死亡，表明存在严重但自我限制的挑战。在益生菌的作用下，攻击动物的改善包括：自愿采食量增加（P益生菌×攻击力= 0.078），沙门氏菌的粪便排泄减少（在感染后第1天为P = 0.028，在感染后第3和第5天为P <0.10） ，降低直肠温度（P益生菌×天= 0.048）和改善绒毛：隐窝比率（P益生菌×挑战<0.001）。此外，在挑战组和非挑战组中都观察到了一般益生菌的益处：PI期腹泻评分降低（P = 0.014），PI第8天的发酵特性得到改善（回肠乙酸升高[P = 0.008]并倾向于降低结肠中的氨浓度[P = 0.078]，通过增加绒毛上皮内淋巴细胞刺激肠道免疫反应（在第8天PI时P = 0.015）和改善的绒毛：隐窝比率（P = 0.011）。总之，多菌株益生菌在减少沙门氏菌挑战中对减少病原体负荷和减轻动物有积极作用。另外，在接受益生菌的所有动物中均记录到肠道健康和免疫力的增强，表明断奶后结果有所改善。

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