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首页> 外文期刊>Frontiers in Immunology >The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains
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The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains

机译：预先存在的交叉反应性中央记忆CD4 T细胞在接种以前未见过的流感病毒株中的作用

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Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome.
机译：流感疫苗接种是预防季节性和大流行性流感的常用方法。预先存在的针对紧密病毒株的抗体可能会损害针对先前未见过的菌株的抗体形成，这一过程称为原始抗原罪。尽管动物模型有一些暗示，但这种预先存在的细胞免疫在该过程中的作用尚不清楚。在这里，我们分析了季节性流感疫苗接种前后健康个体的细胞和体液免疫。根据流感特异性血凝抑制（HI）滴度，将疫苗分为HI阴性和阳性人群，然后进行深入的细胞计数和TCR谱表分析。两组血清学指标均显示在基线时对疫苗株具有交叉反应性T细胞记忆，从而在接种疫苗后产生了大多数疫苗特异性T细胞。相反，从幼稚库中募集了非常有限数量的疫苗特异性T细胞克隆。此外，疫苗特异性中央记忆辅助T细胞的基线数量和该人群的克隆型丰富性直接与疫苗接种效果相关。我们的研究结果表明，故意招募已有的交叉反应性细胞记忆可能有助于改善疫苗接种结果。

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