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首页> 外文期刊>Gastroenterology research and practice >The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis
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The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis

机译：粪便微生物群移植在溃疡性结肠炎患者中的价值：系统评价和荟萃分析

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Background and Aims. Fecal microbiota transplantation (FMT) has challenged the traditional management of ulcerative colitis (UC) in recent years, while it remained controversial. We aimed to provide a systematic protocol of FMT treatment on UC. Methods. Studies reporting on FMT treatment in UC patients were performed. A fixed-effect model was used to assess the efficacy of FMT. Results. Eighteen studies were enrolled (). A pooled proportion of patients who received FMT had a significant efficacy compared to the placebo group (odds ratio (OR) 2.73, ) with a low risk of heterogeneity (, ). The Mayo score decreased to 5 points in a state of mild–moderate activity after FMT treatment, and the optimal range of the Mayo score baseline was 6–9 for FMT administration. Then, the baseline of the Shannon diversity index (SDI) had a negative correlation with the clinical response rate (, ) or remission rate (, ), and the optimal diversity of bacteria was at 7 days to one month. Moreover, the colonoscopy delivery and unrelated fecal donor had slight superiorities of FMT treatment. Conclusion. FMT treatment had a higher efficacy and shorter time-point of early assessment of effectiveness on UC patients compared to traditional therapies. And the optimal FMT delivery and donor were colonoscopy delivery and unrelated donor in clinical practice.
机译：背景和目标。近年来，粪便微生物菌群移植（FMT）挑战了溃疡性结肠炎（UC）的传统治疗方法，但仍存在争议。我们旨在为UC提供FMT治疗的系统协议。方法。进行了有关UC患者FMT治疗的研究报告。使用固定效应模型评估FMT的疗效。结果。招募了18项研究（）。与安慰剂组相比，接受FMT的患者中有一定比例的患者具有显着的疗效（比值比（OR）2.73，），异质性风险低（）。 FMT治疗后，在轻度至中度活动状态下，Mayo评分降低至5分，而FMT管理的Mayo评分基线的最佳范围为6–9。然后，香农多样性指数（SDI）的基线与临床反应率（）或缓解率（）呈负相关，细菌的最佳多样性为7天至一个月。此外，结肠镜检查分娩和无关的粪便供体在FMT治疗方面有轻微优势。结论。与传统疗法相比，FMT治疗对UC患者的疗效更高，早期评估疗效的时间更短。在临床实践中，最佳的FMT输送和供体是结肠镜检查和无关的供体。

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