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首页> 外文期刊>Frontiers in Public Health >Live Poultry Trading Drives China's H7N9 Viral Evolution and Geographical Network Propagation
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Live Poultry Trading Drives China's H7N9 Viral Evolution and Geographical Network Propagation

机译：家禽活体交易推动中国H7N9病毒的进化和地理网络的传播

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The on-going reassortment, human-adapted mutations, and spillover events of novel A(H7N9) avian influenza viruses pose a significant challenge to public health in China and globally. However, our understanding of the factors that disseminate the viruses and drive their geographic distributions is limited. We applied phylogenic analysis to examine the inter-subtype interactions between H7N9 viruses and the closest H9N2 lineages in China during 2010–2014. We reconstructed and compared the inter-provincial live poultry trading and viral propagation network via phylogeographic approach and network similarity technique. The substitution rates of the isolated viruses in live poultry markets and the characteristics of localized viral evolution were also evaluated. We discovered that viral propagation was geographically-structured and followed the live poultry trading network in China, with distinct north-to-east paths of spread and circular transmission between eastern and southern regions. The epicenter of H7N9 has moved from the Shanghai–Zhejiang region to Guangdong Province was also identified. Besides, higher substitution rate was observed among isolates sampled from live poultry markets, especially for those H7N9 viruses. Live poultry trading in China may have driven the network-structured expansion of the novel H7N9 viruses. From this perspective, long-distance geographic expansion of H7N9 were dominated by live poultry movements, while at local scales, diffusion was facilitated by live poultry markets with highly-evolved viruses.
机译：新型A（H7N9）禽流感病毒的持续重组，人类适应性突变和外溢事件对中国乃至全球的公共卫生构成了重大挑战。但是，我们对传播病毒并驱动其地理分布的因素的理解是有限的。我们应用系统发育分析研究了2010-2014年间H7N9病毒与中国最近的H9N2谱系之间的亚型相互作用。我们通过系统地理学方法和网络相似性技术重建并比较了省际活禽交易和病毒传播网络。还评估了活家禽市场中分离的病毒的替代率和局部病毒进化的特征。我们发现病毒的传播具有地理结构，并遵循中国的活禽交易网络，在东西方之间有明显的从北向东的传播途径和循环传播。 H7N9的震中也已从上海-浙江地区转移到广东省。此外，在活家禽市场的分离株中观察到更高的替代率，尤其是那些H7N9病毒。中国的活禽交易可能推动了新型H7N9病毒的网络结构扩展。从这个角度看，H7N9的远距离地理扩展主要是活禽运动，而在本地范围内，活禽市场中传播高度进化的病毒则促进了扩散。

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