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首页> 外文期刊>Frontiers in Public Health >HIV Prevention After Discontinuing Pre-Exposure Prophylaxis: Conclusions From a Case Study
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HIV Prevention After Discontinuing Pre-Exposure Prophylaxis: Conclusions From a Case Study

机译：停止接触前预防后的艾滋病毒预防：一个案例研究的结论

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Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate in combination with emtricitabine (FTC) is a highly effective form of HIV prevention. Endeavors of health-care providers and activists in many countries over the world are directed at making access to PrEP possible, or increasing PrEP use among men-who-have-sex-with-men (MSM). We argue while this effort is necessary, we also need to consider modes of HIV prevention after a period of PrEP use. PrEP uptake is not a one-way street, meaning that individuals may discontinue PrEP use, either voluntarily and involuntarily. Voluntary discontinued PrEP use in conjunction with decreased or no HIV risk exposure is unproblematic, but involuntary discontinuations with continuous high level of HIV risk exposure calls for tailored post-PrEP use HIV prevention. We present a case study of an MSM individual who discontinued PrEP for medical reasons (renal function) and seroconverted soon afterward, to illustrate the need for tailored HIV prevention post-PrEP. Furthermore, we provide additional contexts of PrEP discontinuation leading to populations that are in need for post-PrEP types of HIV prevention. Subsequently, we present suggestions for modes of post-PrEP HIV prevention based on knowledge–communication–choice model. Community organization and health-care providers should consider and prepare their HIV prevention consulting protocols for such types of clients and add post-PrEP HIV prevention measures to their consulting offer.
机译：替诺福韦富马酸替诺福韦酯联用恩曲他滨（FTC）的暴露前预防（PrEP）是一种非常有效的HIV预防方法。全世界许多国家/地区的医疗保健提供者和积极分子的努力都旨在使人们有可能获得PrEP，或在与男性发生性关系的男性中增加PrEP的使用。我们认为，尽管这项工作是必要的，但在使用PrEP一段时间后，我们还需要考虑预防HIV的方式。 PrEP摄取不是一条单向的路，这意味着个人可以自愿和非自愿地终止PrEP的使用。自愿中止使用PrEP并减少或没有HIV风险暴露是没有问题的，但是非自愿中止且持续高水平的HIV风险暴露要求有针对性地在PrPEP后使用HIV预防。我们提供了一个MSM个体的案例研究，该个体由于医学原因（肾功能）而停用PrEP，并在不久后进行血清转化，以说明在PrEP后需要量身定制的HIV预防。此外，我们提供了PrEP停药的其他情况，导致需要进行PrPEP后类型的HIV预防的人群。随后，我们基于知识-交流-选择模型提出了对PrEP后HIV预防模式的建议。社区组织和卫生保健提供者应考虑并准备针对此类客户的艾滋病毒预防咨询协议，并在咨询后增加PrEP后艾滋病毒预防措施。

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