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首页> 外文期刊>Frontiers in Public Health >Vibrio cholerae Transmits Through Water Among the Household Contacts of Cholera Patients in Cholera Endemic Coastal Villages of Bangladesh, 2015a??2016 (CHoBI7 Trial)
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Vibrio cholerae Transmits Through Water Among the Household Contacts of Cholera Patients in Cholera Endemic Coastal Villages of Bangladesh, 2015a??2016 (CHoBI7 Trial)

机译：孟加拉国霍乱地方性沿海村庄霍乱患者家庭接触者中霍乱弧菌通过水传播，2015a ?? 2016（CHoBI7试验）

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Recurrent cholera causes significant morbidity and mortality in cholera endemic estuarine areas of Bangladesh. There have been limited studies to investigate the transmission patterns of V. cholerae associated with cholera in Bangladesh. In this study, we characterized V. cholerae serogroup O1 isolated from 30 cholera patients, 76 household contacts, 119 stored drinking water samples, and 119 water source samples in Bakerganj and Mathbaria, two cholera endemic coastal regions in Bangladesh. Results of phenotypic and molecular characterization of V. cholerae isolates (n = 56) confirmed them to be toxigenic belonging to serogroup O1 biotype El Tor (ET), and possessing cholera toxin of the classical biotype (altered ET). Molecular fingerprinting of the V. cholerae O1 of clinical and water origins determined by PFGE of Not-I- digested genomic DNA showed them to be closely related, as the PFGE banding patterns were highly homogenous. Phylogenetic analysis using dendrogram of cholera patients, household contacts, and household groundwater sources showed isolates within households to be clonally linked, suggesting water as an important vehicle of transmission of cholera in the coastal villages of Bangladesh. Transmission of toxigenic V. cholerae O1 through drinking water in cholera endemic rural settings underscores the urgent need for evidence based water, sanitation, and hygiene interventions promoting safe drinking water to prevent morbidity and mortality related to cholera and other enteric infections in Bangladesh.
机译：在孟加拉国的霍乱地方性河口地区，霍乱的复发导致大量发病和死亡。在孟加拉国，关于霍乱弧菌与霍乱的传播方式进行的研究很少，但有很多。在这项研究中，我们表征了在孟加拉国两个霍乱地方性沿海地区Bakerganj和Mathbaria的30例霍乱患者，76例家庭接触者，119份饮用水样品和119份水源样本中分离的霍乱弧菌血清群O1。霍乱弧菌分离株的表型和分子表征结果（n = 56）证实它们是产毒的，属于血清型O1生物型El Tor（ET），并具有经典生物型霍乱毒素（改变的ET）。临床和水源的霍乱弧菌O1的分子指纹图谱由非I消化的基因组DNA的PFGE确定，显示它们密切相关，因为PFGE谱带图谱高度均一。使用霍乱患者，家庭接触者和家庭地下水源的树状图进行的系统发育分析表明，家庭中的分离株之间存在克隆联系，这表明水是孟加拉国沿海村庄中霍乱传播的重要工具。在霍乱流行的农村地区，通过饮用水传播有毒的霍乱弧菌O1强调了迫切需要循证的水，卫生和卫生干预措施，以促进安全的饮用水来预防孟加拉国霍乱和其他肠道感染的发病率和死亡率。

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