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首页> 外文期刊>Frontiers in Public Health >Prevalence of Nasal Colonization by Methicillin-Resistant Staphylococcus aureus in Persons Using a Homeless Shelter in Kansas City
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Prevalence of Nasal Colonization by Methicillin-Resistant Staphylococcus aureus in Persons Using a Homeless Shelter in Kansas City

机译：在堪萨斯城使用无家可归者收容所的人中耐甲氧西林金黄色葡萄球菌引起的鼻部定植流行

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Nasal colonization of methicillin-resistant Staphylococcus aureus (MRSA) plays an important role in the epidemiology and pathogenesis of disease. Situations of close-quarter contact in groups are generally regarded as a risk factor for community-acquired MRSA strains due to transmission via fomites and person-to-person contact. With these criteria for risk, homeless individuals using shelter facilities, including showers and toilets, should be considered high risk for colonization and infection. The aim of this study was to determine the prevalence of nasal colonization of MRSA in a homeless population compared to established rates of colonization within the public and a control group of subjects from a neighboring medical school campus, and to analyze phylogenetic diversity among the MRSA strains. Nasal samples were taken from the study population of 332 adult participants and analyzed. In addition, participants were surveyed about various lifestyle factors in order to elucidate potential patterns of behavior associated with MRSA colonization. Homeless and control groups both had higher prevalence of MRSA (9.8 and 10.6%, respectively), when compared to the general population reported by previous studies (1.8%). However, the control group had a similar MRSA rate compared to health-care workers (4.6%), while the homeless population had an increased prevalence. Risk factors identified in this study included male gender, age over 50 years, and use of antibiotics within the past 3 months. Phylogenetic relationships between nine of the positive samples from the homeless population were analyzed, showing eight of the nine samples had a high degree of relatedness between the spaA genes of the MRSA strains. This indicates that the same MRSA strain might be transmitted from person-to-person among homeless population. These findings increase our understanding of key differences in MRSA characteristics within homeless populations, as well as risks for MRSA associated with being homeless, such as age and gender, which may then be a useful tool in guiding more effective prevention, treatment, and health care for homeless individuals.
机译：耐甲氧西林金黄色葡萄球菌（MRSA）的鼻部定植在疾病的流行病学和发病机理中起重要作用。由于通过毒气传播和人与人之间的接触，群体中近距离接触的情况通常被认为是社区获得的MRSA菌株的危险因素。根据这些风险标准，应将使用住房设施（包括淋浴和厕所）的无家可归者视为定居和感染的高风险。这项研究的目的是确定无家可归者中MRSA的鼻定殖率与公众和邻近医学院校的对照组人群中确定的定殖率相比，并分析MRSA菌株之间的系统发育多样性。鼻样本取自332名成年参与者的研究人群，并进行了分析。此外，对参加者进行了各种生活方式因素调查，以阐明与MRSA定植相关的潜在行为模式。与先前研究报道的普通人群（1.8％）相比，无家可归者和对照组的MRSA患病率更高（分别为9.8和10.6％）。但是，对照组的MRSA发生率与医护人员（4.6％）相近，而无家可归的人群患病率却更高。在这项研究中确定的危险因素包括男性，50岁以上的年龄以及在过去3个月内使用抗生素。分析了来自无家可归人群的九个阳性样本之间的亲缘关系，显示九个样本中的八个在MRSA菌株的spaA基因之间具有高度相关性。这表明相同的MRSA毒株可能在无家可归的人群中人与人之间传播。这些发现使我们对无家可归人群中MRSA特征的主要差异以及与无家可归者相关的MRSA风险（例如年龄和性别）有了更深入的了解，这可能是指导更有效的预防，治疗和保健的有用工具对于无家可归的人。

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