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首页> 外文期刊>Frontiers in Public Health >Challenges in Estimating Characteristics of Staphylococcus aureus Nasal Carriage Among Humans Enrolled in Surveillance Studies
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Challenges in Estimating Characteristics of Staphylococcus aureus Nasal Carriage Among Humans Enrolled in Surveillance Studies

机译：监测研究人员估计金黄色葡萄球菌鼻腔运输特性的挑战

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Evaluating carriage of Staphylococcus aureus, an opportunistic pathogen of humans and animals capable of causing antibiotic-resistant infections, is epidemiologically important. However, clinical and epidemiological surveillance studies of S. aureus typically rely on characterizing one isolate per individual, which may not represent the actual population diversity in a carrier. The objective of this study was to determine if one isolate is sufficient for determining carrier status of particular strains or characteristics of S. aureus in a healthy (non-hospitalized) human population. We compared spa types, genetic markers (mecA, scn), and antibiotic resistance profiles of 10 S. aureus isolates recovered from a single nasal swab for each of 19 participants (190 isolates total) selected from a cohort of industrial hog operation workers and their household members. Participants included both persistent (n = 10) and intermediate (n = 9) carriers of S. aureus. Among the participants, 17 (89%) carried a single S. aureus spa type intranasally and the other two carried dominant spa types. Less similarity was observed for genes encoded on mobile genetic elements (mecA, scn) and antibiotic resistance profiles. Statistical modeling, based on receiving operating characteristic curves, suggests that three to five isolates may be necessary to accurately assign nasal carriage status for these more variable characteristics. Variability was observed for both persistent and intermediate carriers of S. aureus. These results suggest that surveillance studies that rely on testing one S. aureus isolate are likely to identify predominant spa types but may not fully capture more variable characteristics of S. aureus, including antibiotic resistance. Surveillance studies that rely on testing one isolate may underestimate prevalence of nasal carriage of S. aureus with these more variable characteristics.
机译：评估金黄色葡萄球菌的运输在流行病学上很重要，金黄色葡萄球菌是人和动物的一种机会病原体，能够引起抗药性感染。但是，金黄色葡萄球菌的临床和流行病学监测研究通常依赖于每个个体鉴定一种分离株的特征，这可能并不代表携带者的实际种群多样性。这项研究的目的是确定一种分离株是否足以确定健康（非住院）人群中特定菌株或金黄色葡萄球菌特征的携带者状况。我们比较了从一组工业猪操作工人及其参与者中选择的19名参与者（总共190个分离株）中从单个鼻拭子中回收的10株金黄色葡萄球菌分离株的水疗中心类型，遗传标记（mecA，scn）和抗生素耐药性谱家庭成员。参与者包括金黄色葡萄球菌的持久性（n = 10）和中间性（n = 9）携带者。在参与者中，有17名（89％）鼻腔内携带一种金黄色葡萄球菌水疗类型，其他两种则占主导地位。在移动遗传元件（mecA，scn）和抗生素抗性谱上编码的基因的相似性较少。基于接收到的工作特征曲线的统计模型表明，可能需要三到五个隔离株才能为这些更多易变的特征准确分配鼻腔运输状态。对于金黄色葡萄球菌的持久性和中间性载体均观察到变异性。这些结果表明，依赖于测试一种金黄色葡萄球菌分离物的监测研究可能会确定主要的水疗类型，但可能无法完全捕获金黄色葡萄球菌的更多可变特征，包括抗生素耐药性。依靠测试一种分离株的监测研究可能低估了金黄色葡萄球菌鼻腔运输的流行性，这些特征具有更多可变性。

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