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Impact of Highland Topography Changes on Exposure to Malaria Vectors and Immunity in Western Kenya

机译:高地地形变化对肯尼亚西部疟疾媒介暴露和免疫的影响

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BackgroundIt is almost an axiom that in the African highlands (above 1,500 m) transmission of Plasmodium falciparum is limited primarily by low ambient temperature and that small changes in temperature could result in temporary favorable conditions for unstable transmission within populations that have acquired little functional immunity. The pattern of malaria transmission in the highland plateau ecosystems is less distinct due to the flat topography and diffuse hydrology resulting from numerous streams. The non-homogeneous distribution of larval breeding habitats in east African highlands obviously affects Anopheles spatial distribution which, consequently, leads to heterogeneous human exposure to malaria. Another delicate parameter in the fragile transmission risk of malaria in the highlands is the rapid loss of primary forest due to subsistence agriculture. The implication of this change in land cover on malaria transmission is that deforestation can lead to changes in microclimate of both adult and larval habitats hence increase larvae survival, population density, and gametocytes development in adult mosquitoes. Deforestation has been documented to enhancing vectorial capacity of Anopheles gambiae by nearly 100% compared to forested areas.
机译:背景技术在非洲高地(1500 m以上),恶性疟原虫的传播主要受到环境温度低的限制,而温度的微小变化可能会为暂时获得有利条件的人群提供不稳定的传播条件,而这些人群获得了很少的功能免疫力,这几乎是一个公理。高地高原生态系统中的疟疾传播方式由于平坦的地形和由众多溪流引起的分散水文而不太明显。东非高地幼虫繁殖栖息地的非均匀分布明显影响了按蚊的空间分布,从而导致人类接触疟疾的异质性。高地脆弱的疟疾传播风险中的另一个微妙参数是由于维持生计的农业造成的原始森林的迅速丧失。土地覆盖变化对疟疾传播的影响是,森林砍伐可导致成年和幼虫生境的小气候变化,从而增加成年蚊子的幼虫存活率,种群密度和配子体发育。与森林地区相比,毁林已被证明可使冈比亚按蚊的媒介能力提高近100%。

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