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首页> 外文期刊>Functional Foods In Health And Disease >Effects of six weeks consumption of coconut milk oil on vascular functions and fasting blood glucose and lipid profile in middle-aged male rats
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Effects of six weeks consumption of coconut milk oil on vascular functions and fasting blood glucose and lipid profile in middle-aged male rats

机译：六周食用椰奶油对中年雄性大鼠血管功能和空腹血糖和血脂的影响

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Background: Coconut milk consumption in middle-aged male rats can cause increased blood vessel endothelial nitric oxide synthase (eNOS) and cystathionine- γ- lyase (CSE) protein expression, and decreased fasting blood glucose.Objective: The present study aimed to investigate whether coconut milk oil (CO), the major constituents of the coconut milk, was responsible for those effects.Methods: CO was isolated from dried fresh coconut milk and gavaged (1 and 3 ml/kg) to middle-aged male rats for 6 weeks. Animal body weight and food intake, internal organ weight, blood biochemistry, lipid profile, basal blood pressure and heart rate and vascular functions were investigated.Results: In comparison to a distilled water control group, no differences were observed in any of the parameters studied in the group fed 1 ml/kg of CO except for an increase in retroperitoneal fat accumulation. Feeding 3 ml/kg of CO caused decreased fasting blood glucose, plasma alkaline phosphatase and blood urea nitrogen and liver cell lipid accumulation, but increased retroperitoneal fat tissue. It also caused decreased maximal contractile response of endothelium-intact thoracic aortic rings to phenylephrine although the effect disappeared in the presence of N-nitro-L-arginine (L-NA) or removal of the endothelium. DL-propargylglycine together with L-NA caused a higher contraction to phenylephrine in the CO-treated groups than in the control group. It also caused an increase in vasodilatation to acetylcholine, but not to glyceryl trinitrate, of the phenylephrine pre-contracted aortic rings. CO treatment caused increased vascular wall eNOS and CSE protein expression.Conclusion: CO at a dose of 3 ml/kg causes some decrease in cardiovascular risk factors in middle-aged male rats, although the amount of CO consumption should be limited as it caused an increase in retroperitoneal fat.
机译：背景：中年雄性大鼠食用椰奶可引起血管内皮一氧化氮合酶（eNOS）和胱硫醚-γ-裂解酶（CSE）蛋白表达增加，并降低空腹血糖。椰奶油的主要成分是椰奶油（CO）。方法：从干燥的新鲜椰奶中分离出CO，分别以1和3 ml / kg的剂量灌入中年雄性大鼠，持续6周。 。研究动物体重和食物摄入量，内脏器官重量，血液生化，脂质分布，基础血压和心率以及血管功能。结果：与蒸馏水对照组相比，在任何研究参数上均未观察到差异除腹膜后脂肪蓄积增加外，该组的CO 2摄入量为1 ml / kg。饲喂3 ml / kg的CO会导致空腹血糖，血浆碱性磷酸酶和血液尿素氮减少以及肝细胞脂质蓄积减少，但腹膜后脂肪组织增加。尽管在存在N-硝基-L-精氨酸（L-NA）或去除内皮的情况下，这种作用也消失了，但它也会导致内皮完整的胸主动脉环对苯肾上腺素的最大收缩反应降低。与对照组相比，在CO处理组中，DL-炔丙基甘氨酸与L-NA引起的去氧肾上腺素的收缩更高。它也使去氧肾上腺素预收缩的主动脉环的血管舒张增加，但不增加到乙酰胆碱，但不增加三硝酸甘油酯。结论CO 2的剂量为3 ml / kg，但CO的摄入量受到限制，因为CO的消耗量受到限制，因此CO的处理引起血管壁eNOS和CSE蛋白表达的增加。腹膜后脂肪增加。

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