...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Functional Foods In Health And Disease >Assessment of anti-inflammatory effects of Japanese Kampo medicine versus functional foods
【24h】

Assessment of anti-inflammatory effects of Japanese Kampo medicine versus functional foods

机译：评估日本Kampo药物与功能食品的抗炎作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Traditional Japanese drugs called Kampo medicine are widely used in Japan. Each Kampo medicine consists of several crude drugs, most of which are derived from medicinal plants. Clinical administration has empirically evaluated the effects of Kampo medicine. In contrast,functional foods are prepared from foods and edible plants (e.g., herbs, vegetables, and fruits). Due to the relatively low content of a pharmacologically active constituents in functional foods, their effectiveness has not been well evaluated and thus should be better investigated. Kampo medicine and functional foods have beneficial effects for humans, and many of them exhibit anti-inflammatory effects. Here, we discuss the principles and methods to assess the anti- inflammatory effects of functional foods and Kampo medicine.To investigate pharmacological effects of functional foods and Kampo medicines, theirconstituents should be isolated to identify their chemical structures. Cell-based studies are commonly performed to evaluate anti-inflammatory effects of the constituents in Kampo medicine and functional foods. Primary cultured rat hepatocytes are used and produce pro- inflammatory mediators, including nitric oxide. When an extract from a Kampo medicine, functional food, or a respective constituent is added to the medium, pro-inflammatory mediator production decreases, and the anti-inflammatory activity is estimated. Animal experiments have been performed using disease models, such as the endotoxemia model for animals, to which bacterial endotoxin is administered. Administering an effective functional food or Kampo medicine improves the survival of the model animals. The action of the anti- inflammatory effects of functional foods and Kampo medicines can be investigated by the above-mentioned methods. The studies using cells and animals will provide a basis for the safe and effective use of functional foods and Kampo medicine in humans to treat diseases or improve health conditions.
机译：在日本，被广泛使用的传统日本药称为甘宝药。每种汉方药均由几种粗制药物组成，其中大部分是从药用植物中提取的。临床行政管理已凭经验评估了Kampo药物的疗效。相反，功能性食物是由食物和可食用植物（例如草药，蔬菜和水果）制成的。由于功能食品中药理活性成分的含量较低，因此尚未对其效果进行很好的评估，因此应进行更好的研究。汉方药和功能性食品对人类有益，其中许多具有抗炎作用。在此，我们讨论了评估功能性食品和Kampo药物的抗炎作用的原理和方法。要研究功能性食品和Kampo药物的药理作用，应分离它们的成分以鉴定其化学结构。通常进行基于细胞的研究，以评估汉方药和功能性食品中成分的抗炎作用。使用原代培养的大鼠肝细胞并产生促炎性介质，包括一氧化氮。当将来自Kampo药品，功能性食品或相应成分的提取物添加到培养基中时，促炎介质的产生减少，并且估计了抗炎活性。已经使用疾病模型进行了动物实验，例如动物的内毒素血症模型被施以细菌内毒素。管理有效的功能性食品或Kampo药物可改善模型动物的存活率。可以通过上述方法研究功能性食品和Kampo药物的抗炎作用。使用细胞和动物进行的研究将为在人类中安全有效地使用功能性食品和汉方药提供基础，以治疗疾病或改善健康状况。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号