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首页> 外文期刊>Functional Foods In Health And Disease >Passionflower extract improves diurnal quality of life in Japanese subjects with anxiety: A randomized, placebo-controlled, double-blind trial
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Passionflower extract improves diurnal quality of life in Japanese subjects with anxiety: A randomized, placebo-controlled, double-blind trial

机译：西番莲提取物可改善日本焦虑症患者的生活质量：一项随机，安慰剂对照，双盲试验

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Background and objective: Passiflora incarnata (passionflower) has traditionally been used to treat insomnia and anxiety. We recently reported that an aqueous ethanol extract of passionflower (PFE) and its flavonoid glycosides, enhanced the expression of Period (Per) 2, a clock gene, in mouse liver and fibroblasts. However, the influence of PFE on daily activities or emotions has not been examined in humans.Aim: This study conducted a clinical trial of PFE supplementation in healthy Japanese participants and investigate if PFE influences sleep and emotions.Methods: This randomized, double-blind, placebo-controlled study examined the effects of PFE (200 mg daily) containing 3% flavonoid glycosides (6 mg daily). We enrolled 44 Japanese men and women who were reluctant to work, do house chores or engage in irregular shift work. All subjects were randomly allocated into either the PFE group (n=22) or the placebo group (n=22) using a computerized random-number generator. Capsules containing either PFE or placebo were administered for 12 weeks between August 2017 and January 2018. Both emotional status and sleep quality were evaluated by using the Japanese version of Medical Outcomes Study Short-Form 36-Item Health (SF-36) questionnaire and the Oguri-Shirakawa-Azumi (OSA) sleep inventory score at 6- and 12-week of ingestion.Results: The per protocol set comprised 20 subjects in the PFE group and 18 subjects (20 subjects for OSA and safety evaluation) in the placebo group. After intake of PFE (200 mg/day) for 6 weeks, some of the SF-36 domain scores were significantly improved compared with those of the placebo group, including the scores for role/social component summary, social functioning, and role-emotional. After 12 weeks, the scores for mental component summary and vitality showed significant improvement in the subjects taking PFE (200 mg/day) compared to those taking placebo. In contrast, none of the OSA sleep score parameters were significantly improved by PFE compared with placebo. Laboratory tests did not reveal any abnormalities suggesting adverse effects of PFE.Conclusions: Intake of PFE (200 mg/day for 12 weeks) improved several emotional parameters related to daytime social and mental activities. PFE was suggested to be useful for improving anxiety.Trial Registration: UMIN-CTR: UMIN000028622Foundation: Oryza Oil & Fat Chemical Co., Ltd.
机译：背景和目的：西番莲（西番莲）传统上被用于治疗失眠和焦虑症。最近，我们报道了西番莲（PFE）及其类黄酮糖苷的乙醇水溶液提取物增强了小鼠肝脏和成纤维细胞中Clock基因Perio 2的表达。然而，人类尚未研究过PFE对日常活动或情绪的影响。目的：本研究在健康的日本参与者中进行了补充PFE的临床试验，并研究了PFE是否会影响睡眠和情绪。方法：这项随机，双盲的研究安慰剂对照研究检查了含有3％黄酮苷（每天6 mg）的PFE（每天200 mg）的作用。我们招收了44位不愿工作，做家务或从事不定期轮班工作的日本男女。使用计算机随机数发生器将所有受试者随机分为PFE组（n = 22）或安慰剂组（n = 22）。在2017年8月至2018年1月之间，对含有PFE或安慰剂的胶囊进行了为期12周的治疗。使用日文版的医学成果研究简短的36项健康问卷（SF-36）和摄入6周和12周时，小栗-白川-淳（OSA）的睡眠量表得分。结果：每种方案集包括PFE组中的20名受试者和安慰剂组中的18名受试者（20名OSA和安全性评估受试者）。 。摄入PFE（200 mg /天）6周后，与安慰剂组相比，一些SF-36域得分得到了显着改善，包括角色/社交成分摘要，社交功能和角色情感得分。 12周后，与服用安慰剂的受试者相比，服用PFE（200毫克/天）的受试者的精神成分摘要和活力得分显着提高。相反，与安慰剂相比，PFE没有显着改善OSA睡眠评分参数。实验室检查未发现任何暗示PFE不良反应的异常情况。结论：PFE的摄入（200 mg /天，连续12周）改善了与白天社交和心理活动有关的几种情绪参数。建议使用PFE来改善焦虑症。试验注册：UMIN-CTR：UMIN000028622基金会：Oryza Oil＆Fat Chemical Co.，Ltd.

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