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首页> 外文期刊>Frontiers in Aging Neuroscience >The impacts of a GO-game (Chinese chess) intervention on Alzheimer disease in a Northeast Chinese population
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The impacts of a GO-game (Chinese chess) intervention on Alzheimer disease in a Northeast Chinese population

机译：GO游戏（中国象棋）对东北中国人口阿尔茨海默氏病的影响

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A GO game can enhance mental health, but its effects on Alzheimer Disease (AD) remains unknown. To address the issue, 147 AD patients were randomly assigned into control (without GO-game intervention), Short-time GO-Game Intervention (SGGI, 1 h daily) and Long-time GO-game Intervention (LGGI, 2 h daily) groups. After 6-month follow-up, the game reduced the mean score of Montgomery-Asberg Depression Rating Scales (MADRS) of 4.72 (95% CI, 0.69 to 9.12) and Hospital Anxiety and Depression Scale (HADS) of 1.75 (95% CI, 0.17–3.68), and increased the mean score of Global Assessment of Functioning (GAF) of 4.95 (95% CI, ?1.37–9.18) and RAND-36 of 4.61 (95% CI, ?2.75–11.32) ( P < 0.05 via controls). A GO-game intervention improved 9 of 11 items of KICA-dep (Kimberley Indigenous Cognitive Assessment of Depression). Meanwhile, serum levels of brain derived neurotrophic factor (BDNF) were higher in SGGI and LGGI groups (24.02 ± 7.16 and 28.88 ± 4.12 ng/ml respectively, P = 0.051) than those in controls (17.28 ± 7.75 ng/ml) ( P < 0.001). The serum levels of BDNF showed a negative relation with MADRS and a positive relation with RAND-36 ( P < 0.01). A GO-game intervention ameliorates AD manifestations by up-regulating BDNF levels.
机译：GO游戏可以增强心理健康，但对阿尔茨海默病（AD）的影响仍未知。为了解决该问题，将147名AD患者随机分为对照组（无GO游戏干预），短期GO游戏干预（SGGI，每天1小时）和长期GO游戏干预（LGGI，每天2小时）。组。经过6个月的跟踪调查，该游戏将蒙哥马利-阿斯伯格抑郁量表（MADRS）的平均得分降低了4.72（95％CI，0.69至9.12），医院焦虑和抑郁量表（HADS）的平均得分降低了1.75（95％CI） ，0.17–3.68），全局功能评估（GAF）的平均得分提高了4.95（95％CI，？1.37–9.18）和RAND-36提高了4.61（95％CI，？2.75–11.32）（P < 0.05（通过对照）。 GO游戏干预改善了11项KICA-dep（金伯利抑郁原住民认知评估）中的9项。同时，SGGI和LGGI组的血清脑源性神经营养因子（BDNF）水平高于对照组（17.28±7.75 ng / ml）（分别为24.02±7.16和28.88±4.12 ng / ml，P = 0.051）（P <0.001）。血清BDNF水平与MADRS呈负相关，与RAND-36呈正相关（P <0.01）。 GO游戏干预可通过上调BDNF水平来改善AD表现。

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