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首页> 外文期刊>Frontiers in Aging Neuroscience >Cingulate Cortex Atrophy Is Associated With Hearing Loss in Presbycusis With Cochlear Amplifier Dysfunction
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Cingulate Cortex Atrophy Is Associated With Hearing Loss in Presbycusis With Cochlear Amplifier Dysfunction

机译：扣带回皮质萎缩与耳蜗放大器功能障碍的老年性耳聋相关

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Age-related hearing loss is associated with cognitive decline and has been proposed as a risk factor for dementia. However, the mechanisms that relate hearing loss to cognitive decline remain elusive. Here, we propose that the impairment of the cochlear amplifier mechanism is associated with structural brain changes and cognitive impairment. Ninety-six subjects aged over 65 years old (63 female and 33 male) were evaluated using brain magnetic resonance imaging, neuropsychological and audiological assessments, including distortion product otoacoustic emissions as a measure of the cochlear amplifier function. All the analyses were adjusted by age, gender and education. The group with cochlear amplifier dysfunction showed greater brain atrophy in the cingulate cortex and in the parahippocampus. In addition, the atrophy of the cingulate cortex was associated with cognitive impairment in episodic and working memories and in language and visuoconstructive abilities. We conclude that the neural abnormalities observed in presbycusis subjects with cochlear amplifier dysfunction extend beyond core auditory network and are associated with cognitive decline in multiple domains. These results suggest that a cochlear amplifier dysfunction in presbycusis is an important mechanism relating hearing impairments to brain atrophy in the extended network of effortful hearing.
机译：与年龄有关的听力损失与认知能力下降有关，并已被认为是痴呆的危险因素。但是，将听力丧失与认知能力下降相关的机制仍然难以捉摸。在这里，我们建议耳蜗放大器机制的损害与大脑结构的变化和认知障碍有关。使用大脑磁共振成像，神经心理学和听力学评估，包括畸变产物耳声发射作为耳蜗放大器功能的一项指标，对65岁以上的96名受试者（63名女性和33名男性）进行了评估。所有分析均根据年龄，性别和教育程度进行了调整。耳蜗放大器功能障碍的组在扣带状皮层和海马旁显示出更大的脑萎缩。此外，扣带皮层的萎缩与情节和工作记忆以及语言和视觉建构能力方面的认知障碍有关。我们得出的结论是，在患有耳蜗放大器功能障碍的老年患者中观察到的神经异常超出了核心听觉网络，并与多个领域的认知能力下降有关。这些结果表明，在老年性耳聋中耳蜗放大器功能异常是在努力的听力扩展网络中将听力障碍与脑萎缩相关的重要机制。

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