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首页> 外文期刊>Marine Drugs >Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery
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Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery

机译：海洋微生物-无脊椎动物集合体：解决药物发现初始步骤中“供应问题”的观点

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The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the “blue gold” in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.
机译：在紧急寻求新药的过程中，与海洋天然产物（MNP）相关的化学多样性被一致认为是“蓝金”。因此，在过去的几十年中，特别是从海洋无脊椎动物中发现了文献中公布的MNP的发现显着增加。然而，目前尚不清楚目标代谢物是源自海洋无脊椎动物本身还是源自其微生物共生体。该问题强调了与为药物开发管道的早期阶段提供所需的生物质缺乏相关的重大挑战。本综述讨论了应对此类挑战的潜在解决方案，尤其着重于从头到尾的水产养殖中培养无脊椎动物全生物（微生物-无脊椎动物组合）的创新方法，以及从这些微生物共生体中发现和初步生产生物活性化合物的方法。

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