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首页> 外文期刊>Marine Drugs >In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice
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In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice

机译：褐藻黄素，一种海洋类胡萝卜素，与肉瘤180（S180）异种移植小鼠中的STAT3 / EGFR信号下调相关的体内诱导凋亡。

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Previous in vitro researches have showed that fucoxanthin, a natural carotenoid isolated from sargassum, can inhibit proliferation or induce apoptosis in human neuroblastoma, hepatoma, leukemia, colon carcinoma, prostate cancer or urinary bladder cancer cells. But the precise mechanism by which fucoxanthin exerts anticarcinogenic effects is not yet fully understood. In this study, we performed an in vivo study to investigate the anti-tumor effect and mechanisms of fucoxanthin on xenografted sarcoma 180 (S180) in mice. Results revealed that fucoxanthin significantly inhibited the growth of sarcoma at the dose of 50 or 100 mg/kg. TUNEL analysis showed that the number of positive cells in the fucoxanthin-treated group was higher than that in the control group. Western blotting analysis also revealed the suppressed expression of bcl-2 and enhanced expression of cleaved caspase-3 by fucoxanthin. In addition, immunohistochemistry analysis and Western blotting analysis showed that fucoxanthin significantly decreased the expressions of survivin and vascular endothelial growth factor (VEGF). Most importantly, fucoxanthin inhibited the expressions of the epidermal growth factor receptor (EGFR) and STAT3 and phosphorylated STAT3 proteins. These results indicated that in vivo induction of apoptosis by fucoxanthin is associated with down-regulating STAT3/EGFR signaling in S180 xenografts-bearing mice.
机译：先前的体外研究表明，岩藻黄质是一种从海藻中分离出来的天然类胡萝卜素，可以抑制人神经母细胞瘤，肝癌，白血病，结肠癌，前列腺癌或膀胱癌细胞的增殖或诱导细胞凋亡。但是，尚未完全了解岩藻黄质发挥抗癌作用的确切机制。在这项研究中，我们进行了一项体内研究，以研究岩藻黄质对小鼠异种移植肉瘤180（S180）的抗肿瘤作用及其机制。结果显示，岩藻黄质以50或100 mg / kg的剂量显着抑制肉瘤的生长。 TUNEL分析显示，岩藻黄质治疗组的阳性细胞数量高于对照组。蛋白质印迹分析还揭示了岩藻黄质抑制了bcl-2的表达并增强了裂解的caspase-3的表达。此外，免疫组织化学分析和蛋白质印迹分析表明岩藻黄质显着降低了survivin和血管内皮生长因子（VEGF）的表达。最重要的是，岩藻黄质抑制表皮生长因子受体（EGFR）和STAT3和磷酸化STAT3蛋白的表达。这些结果表明岩藻黄质在体内诱导细胞凋亡与S180异种移植小鼠中STAT3 / EGFR信号转导下调有关。

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