Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action ?

Alejandro M. S. Mayer; Abimael D. Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani

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Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action ?

机译：2012-2013年的海洋药理学：具有抗菌，抗糖尿病，抗真菌，抗炎，抗原生动物，抗结核和抗病毒活性的海洋化合物;影响免疫和神经系统，以及其他各种作用机制？

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The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to the United States, reported findings on the preclinical pharmacology of 257 marine compounds. The preclinical pharmacology of compounds isolated from marine organisms revealed antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral and anthelmitic pharmacological activities for 113 marine natural products. In addition, 75 marine compounds were reported to have antidiabetic and anti-inflammatory activities and affect the immune and nervous system. Finally, 69 marine compounds were shown to display miscellaneous mechanisms of action which could contribute to novel pharmacological classes. Thus, in 2012–2013, the preclinical marine natural product pharmacology pipeline provided novel pharmacology and lead compounds to the clinical marine pharmaceutical pipeline, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.

机译：系统地审阅了2012年至2013年经过同行评审的海洋药理学文献，与本系列的1998年至2011年的评论一致。除美国外，还有42个国家的科学家在2012年至2013年间进行了海洋药理学研究，报告了257种海洋化合物的临床前药理学发现。从海洋生物中分离出的化合物的临床前药理学发现，对113种海洋天然产品具有抗菌，抗真菌，抗原生动物，抗结核，抗病毒和驱虫药的药理活性。此外，据报告有75种海洋化合物具有抗糖尿病和抗炎活性，并影响免疫和神经系统。最后，显示出69种海洋化合物显示出多种作用机制，这些机制可能有助于新型药理学类别。因此，在2012-2013年间，临床前海洋天然产物药理管线为临床海洋药物管线提供了新颖的药理学和先导化合物，并为多种全球疾病类别的潜在新颖治疗方法做出了重要贡献。

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《Marine Drugs》 |2017年第9期|共页
作者
Alejandro M. S. Mayer; Abimael D. Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani;
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1. Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action † [J] . Abimael D. Rodr#xED, guez, Alejandro M. S. Mayer, Marine Drugs . 2013,第7期

机译：2009-2011年的海洋药理学：具有抗菌，抗糖尿病，抗真菌，抗炎，抗原生动物，抗结核和抗病毒活性的海洋化合物;影响免疫和神经系统以及其他各种作用机制†
2. Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. [J] . Mayer AM, Rodriguez AD, Berlinck RG Biochimica et Biophysica Acta. General Subjects . 2009,第5期

机译：2005-6年间的海洋药理学：具有驱虫，抗菌，抗凝，抗真菌，抗炎，抗疟，抗原生动物，抗结核和抗病毒活性的海洋化合物;影响心血管，免疫和神经系统以及其他各种作用机制。
3. Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; Affecting the immune and nervous system, and other miscellaneous mechanisms of action [J] . Mayer A.M.S., Rodríguez A.D., Berlinck R.G.S., Comparative biochemistry and physiology. Toxicology & pharmacology: CBP . 2011,第2期

机译：2007-8年的海洋药理学：具有抗菌，抗凝血，抗真菌，抗炎，抗疟疾，抗原生动物，抗结核和抗病毒活性的海洋化合物;影响免疫和神经系统，以及其他各种作用机制
4. Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial Antidiabetic Antifungal Anti-Inflammatory Antiprotozoal Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems and Other Miscellaneous Mechanisms of Action [O] . Alejandro M. S. Mayer, Abimael D. Rodríguez, Orazio Taglialatela-Scafati, 2017

机译：2012-2013年的海洋药理学：具有抗菌抗糖尿病抗真菌抗炎抗原生动物抗结核和抗病毒活性的海洋化合物；影响免疫和神经系统以及其他各种作用机制
5. Marine Pharmacology in 2012-2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action [O] . Mayer, Alejandro M. S, Rodríguez, Abimael D, Taglialatela Scafati, Orazio, 2017

机译：2012 - 2013年海洋药理学：具有抗菌，抗糖尿病，抗真菌，抗炎，抗原虫，抗结核和抗病毒活性的海洋化合物;影响免疫和神经系统以及其他各种行动机制

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action ?

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