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首页> 外文期刊>Frontiers in Neuropharmacology >A Single Dose of Methylprednisolone Improves Aversive Memory Consolidation and Extinction in Rats
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A Single Dose of Methylprednisolone Improves Aversive Memory Consolidation and Extinction in Rats

机译：单剂量甲基强的松龙可改善大鼠的厌恶记忆巩固和消灭

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Aversive memory is essential for survival, but in some situations its exacerbation can be potentially dangerous. There are several ways to modulate memory, among them, through stress-related hormones physiological release or administration of exogenous substances analogous to them. Recently, our group shown that a chronic treatment with a low dose of methylprednisolone (MP) is able to promote memory persistence in rats. Herein, we evaluate if a single intraperitonial dose of MP (5 mg/kg) is able to modulate aversive memory consolidation and promote memory persistence and extinction in rats. For this, two experiments were carried out. In the first one, we demonstrated that a single IP MP administration in specific times after inhibitory avoidance training improved memory consolidation and persistence. In the second experiment, we verified that a single IP MP administration 2h after IA extinction training promoted memory extinction. This results suggest a possible new clinical applicability for MP on the aversive memory disorders, as post-traumatic stress.
机译：厌恶记忆对于生存至关重要，但在某些情况下，恶化可能具有潜在的危险。通过应激相关激素的生理释放或类似于它们的外源物质的给药，有几种调节记忆的方法。最近，我们的小组表明，低剂量甲基强的松龙（MP）的长期治疗能够促进大鼠的记忆力持久性。在本文中，我们评估了腹膜内单剂量的MP（5 mg / kg）是否能够调节厌恶性记忆巩固并促进大鼠的记忆持久性和灭绝。为此，进行了两个实验。在第一个实验中，我们证明了在抑制性避免训练后的特定时间进行一次IP MP管理可以改善记忆巩固和持久性。在第二个实验中，我们验证了在IA灭绝训练后2小时进行一次IP MP注射可促进记忆消失。该结果表明MP作为创伤后应激在厌恶性记忆障碍上可能具有新的临床适用性。

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