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首页> 外文期刊>Frontiers in Neuropharmacology >Effects of Cocaine and Fasting on the Intake of Individual Macronutrients in Rats
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Effects of Cocaine and Fasting on the Intake of Individual Macronutrients in Rats

机译：可卡因和禁食对大鼠个别常量营养素摄入的影响

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Obesity is a significant problem, and increased food intake is thought to underlie much of the increase in obesity levels. Recently, there has been much discussion and debate about the role of the individual macronutrients, carbohydrates, fat, and protein, in the rise in obesity levels and its associated comorbidities, but overall there has been little study of how different treatments and stimuli that affect feeding impact the intake of individual macronutrients. In these studies, we tested whether two treatments leading to altered feeding, acute cocaine injection and an acute fast, differentially affect the intake of individual macronutrients using a three diet choice paradigm. Cocaine strongly inhibited the intake of each individual test diet (carbohydrate, fat, and protein), but there were no differences between its effects on the intakes of each individual diet. In contrast, an acute fast had little effect on the intake of any of the diets and did not differentially affect the intake of the three test diets. Thus, these studies demonstrate that cocaine can effectively inhibit the intake of feeding independent of its macronutrient content, and significantly advance our understanding of the neural regulation of individual macronutrient intake.
机译：肥胖是一个重大问题，人们认为增加食物摄入量是肥胖水平增加的主要原因。近年来，关于各种常量营养素，碳水化合物，脂肪和蛋白质在肥胖症水平及其相关合并症中的作用进行了大量的讨论和辩论，但总体而言，很少有关于不同的治疗方法和刺激如何影响肥胖的研究。喂食会影响单个常量营养素的摄入。在这些研究中，我们使用三种饮食选择范式测试了两种导致喂养方式改变的方法，急性可卡因注射和快速禁食是否会分别影响个体大量营养素的摄入。可卡因强烈抑制每种饮食（碳水化合物，脂肪和蛋白质）的摄入量，但对每种饮食的摄入量之间没有差异。相反，急性禁食对任何饮食的摄入量几乎没有影响，并且对三种测试饮食的摄入量没有差异。因此，这些研究表明可卡因可以有效地抑制摄食量，而与它的大量营养素含量无关，并且可以极大地增进我们对单个大量营养素摄入的神经调节的理解。

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