• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Neuropharmacology >The Configuration of the Perivascular System Transporting Macromolecules in the CNS
【24h】

The Configuration of the Perivascular System Transporting Macromolecules in the CNS

机译：中枢神经系统中传输大分子的血管周围系统的配置

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Large blood vessels entering the CNS are surrounded by perivascular spaces that communicate with the cerebrospinal fluid and, at their termini, with the interstitial space. Solutes and particles can translocate along these perivascular conduits, reportedly in both directions. Recently, this prompted a renewed interest in the intrathecal therapy delivery route for CNS-targeted therapeutics. However, the extent of the CNS coverage by the perivascular system is unknown, making the outcome of drug administration to the CSF uncertain. We traced the translocation of model macromolecules from the CSF into the CNS of rats and non-human primates. Conduits transporting macromolecules were found to extend throughout the parenchyma from both external and internal (fissures) CNS boundaries, excluding ventricles, in large numbers, on average ca. 40 channels per mm2 in rats and non-human primates. The high density and depth of extension of the perivascular channels suggest that the perivascular route can be suitable for delivery of therapeutics to parenchymal targets throughout the CNS.
机译：进入中枢神经系统的大血管被血管周围的空间所包围，血管周围的空间与脑脊液以及在其末端的间质空间相通。溶质和颗粒可沿这些血管周导管沿两个方向移位。近来，这引起了对针对CNS靶向的治疗剂的鞘内治疗递送途径的新的兴趣。但是，血管周围系统对中枢神经系统的覆盖程度尚不清楚，这使得向脑脊液给药的结果不确定。我们追踪了模型大分子从脑脊液到大鼠和非人类灵长类动物中枢神经系统的易位。发现运输大分子的管道平均从外部和内部（裂隙）中枢神经系统边界（心室除外）在整个薄壁组织中延伸。在大鼠和非人类灵长类动物中，每平方毫米40个通道。血管周通道的高密度和延伸深度表明，血管周途径可适合于将治疗剂递送至整个CNS中的实质目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号