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首页> 外文期刊>Frontiers in Neuropharmacology >Exercise Attenuates Anabolic Steroids-Induced Anxiety via Hippocampal NPY and MC4 Receptor in Rats
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Exercise Attenuates Anabolic Steroids-Induced Anxiety via Hippocampal NPY and MC4 Receptor in Rats

机译：运动通过大鼠海马NPY和MC4受体减轻类固醇类固醇诱导的焦虑

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The aim of our study was to evaluate the effects of chronic administration of nandrolone-decanoate (ND) or testosterone-enanthate (TE) in supraphysiological doses and a prolonged swimming protocol, alone and in combination with ND or TE, on anxiety-like behavior in rats. We investigated the immunohistochemical alterations of the hippocampal neuropeptide Y (NPY) and melanocortin 4 receptor (MC4R) neurons, as a possible underlying mechanism in a modulation of anxiety-like behavior in rats. Both applied anabolic androgenic steroids (AASs) induced anxiogenic effect accompanied with decreased serum and hippocampal NPY. The exercise-induced anxiolytic effect was associated with increased hippocampal NPY expression. ND and TE increased the number of MC4R, while the swimming protocol was followed by the reduction of MC4R in the CA1 region of the hippocampus. However, NPY/MC4R ratio in hippocampus was lowered by AASs and elevated by exercise in all hippocampal regions. An augmentation of this ratio strongly and positively correlated to increased time in open arms of elevated plus maze, in the context that indicates anxiolytic effect. Our findings support the conclusion that alterations in both hippocampal NPY and MC4R expression are involved in anxiety level changes in rats, while their quantitative relationship (NPY/MC4R ratio) is even more valuable in the estimation of anxiety regulation than individual alterations for both NPY and MC4R expression in the hippocampus.
机译：我们研究的目的是评估超生理剂量长期服用nandrolone-decanoate（ND）或睾丸激素-庚酸酯（TE）和长期游泳方案（单独或与ND或TE联合使用）对焦虑样行为的影响在大鼠中。我们调查了海马神经肽Y（NPY）和黑皮质素4受体（MC4R）神经元的免疫组织化学改变，作为调节大鼠焦虑样行为的潜在潜在机制。两者均使用合成代谢雄激素类固醇（AASs）诱导的促焦虑作用，并伴有血清和海马NPY降低。运动诱导的抗焦虑作用与海马NPY表达增加有关。 ND和TE增加了MC4R的数量，而游泳方案后海马CA1区的MC4R减少。然而，在所有海马区域，AAS均可降低海马中的NPY / MC4R比率，而运动则可提高海马中的NPY / MC4R比率。在表明抗焦虑作用的情况下，该比例的增加与高架迷宫的张开臂​​中时间的增加强烈正相关。我们的发现支持以下结论：海马NPY和MC4R表达的改变均与大鼠焦虑水平的变化有关，而它们的定量关系（NPY / MC4R比）在评估焦虑调节方面比对NPY和MC4R的单独改变更有价值。海马中的MC4R表达。

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