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首页> 外文期刊>Frontiers in Neuropharmacology >Social Defeat Stress Decreases mRNA for Monoamine Oxidase A and Increases 5-HT Turnover in the Brain of Male Nile Tilapia (Oreochromis niloticus)
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Social Defeat Stress Decreases mRNA for Monoamine Oxidase A and Increases 5-HT Turnover in the Brain of Male Nile Tilapia (Oreochromis niloticus)

机译：社交失败压力降低男性尼罗罗非鱼（Oreochromis niloticus）脑中单胺氧化酶A的mRNA并增加5-HT转换。

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摘要

Stress induces various neurobiological responses and causes psychiatric disorders, including depression. Monoamine oxidase A (MAO-A) plays an important role in various functions of the brain, such as regulation of mood, anxiety and aggression, and dysregulation of MAO-A is observed in stress-related psychiatric disorders. This study addressed the question whether acute social stress induces changes to transcriptional and/or post-transcriptional regulation of MAO-A expression in the brain. Using male Nile tilapia (Oreochromis niloticus), we investigated whether acute social stress, induced by the presence of a dominant male fish, changes the expression of MAO-A. We measured gene expression of MAO-A by quantitative PCR, enzymatic activity of MAO-A by the luminescent method, and 5-HT and 5-HIAA levels by liquid chromatography–mass spectrometry in the brain of socially stressed and control fish. Socially stressed males showed decreased MAO-A mRNA levels, consistent MAO-A enzymatic activity, increased 5-HT turnover in the brain, and elevated plasma cortisol levels, compared to controls. Our results suggest that acute social stress suppresses the transcription of MAO-A gene, enhances 5-HT metabolism but does not affect the production of MAO-A protein.
机译：压力会诱发各种神经生物学反应，并导致精神疾病，包括抑郁症。单胺氧化酶A（MAO-A）在大脑的各种功能（例如情绪，焦虑和攻击性调节）中起重要作用，并且在与压力有关的精神病中观察到MAO-A失调。这项研究解决了以下问题：急性社会压力是否会诱导大脑中MAO-A表达的转录和/或转录后调控发生变化。使用雄性尼罗罗非鱼（Oreochromis niloticus），我们调查了由显性雄性鱼类引起的急性社会压力是否会改变MAO-A的表达。我们通过定量PCR测量了社会紧张和控制鱼类大脑中MAO-A的基因表达，通过发光法测量了MAO-A的酶活性，并通过液相色谱-质谱法测定了5-HT和5-HIAA的水平。与对照组相比，受到社会压力的男性显示出降低的MAO-A mRNA水平，一致的MAO-A酶活性，增加的脑内5-HT转化率和升高的血浆皮质醇水平。我们的结果表明，急性的社会压力抑制了MAO-A基因的转录，增强了5-HT代谢，但不影响MAO-A蛋白的产生。

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