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首页> 外文期刊>Frontiers in Neuropharmacology >Verapamil Blocks Scopolamine Enhancement Effect on Memory Consolidation in Passive Avoidance Task in Rats
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Verapamil Blocks Scopolamine Enhancement Effect on Memory Consolidation in Passive Avoidance Task in Rats

机译：维拉帕米阻断东co碱对大鼠被动回避任务中记忆巩固的增强作用。

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Our recent data have indicated that scopolamine, a nonselective muscarinic receptor antagonist, improves memory consolidation, in a passive avoidance task, tested in rats. It has been found that verapamil, a phenylalkylamine class of the L-type voltage-dependent calcium channel antagonist, inhibits [3H] N-methyl scopolamine binding to M1 muscarinic receptors. However, there are no data about the effect of verapamil on memory consolidation in the passive avoidance task, in rats. The purpose of the present study was to examine the effects of verapamil (0.5, 1.0, 2.5, 5.0, 10 or 20 mg/kg i.p.) as well as the interaction between scopolamine and verapamil on memory consolidation in the step-through passive avoidance task, in Wistar rats. Our results showed that verapamil (1.0 and 2.5 mg/kg) administered immediately after the acquisition task significantly increased the latency of the passive avoidance response, on the 48h retested trial, improving memory consolidation. On the other hand, verapamil in a dose of 5 mg/kg, that per se does not affect memory consolidation, significantly reversed the memory consolidation improvement induced by scopolamine (1 mg/kg, i.p., administered immediately after verapamil treatment) but did not change the passive avoidance response in rats treated by an ineffective dose of scopolamine (30 mg/kg). In conclusion, the present data suggest that 1) the post-training administration of verapamil, dose-dependently, improves the passive avoidance response, 2) verapamil, in ineffective dose, abolished the improvement of memory consolidation effect of scopolamine and 3) exists interaction between cholinergic muscarinic receptors and calcium homeostasis related mechanisms in the consolidation of emotional memory.
机译：我们的最新数据表明，东pol碱，一种非选择性毒蕈碱受体拮抗剂，在被动回避任务中，在大鼠中进行了测试，可改善记忆巩固。已发现维拉帕米，一种L型电压依赖性钙通道拮抗剂的苯基烷基胺，可抑制[3H] N-甲基东sco碱与M1毒蕈碱受体的结合。但是，在被动回避任务中，没有关于维拉帕米对记忆巩固的影响的数据。本研究的目的是在逐步被动回避任务中研究维拉帕米（0.5、1.0、2.5、5.0、10或20 mg / kg ip）的作用以及东pol碱和维拉帕米之间对记忆巩固的相互作用，在Wistar大鼠中。我们的结果表明，在48小时重新测试的试验中，获取任务后立即服用维拉帕米（1.0和2.5 mg / kg）会显着增加被动回避反应的潜伏期，从而改善记忆巩固。另一方面，维拉帕米本身并不影响记忆巩固的5 mg / kg剂量，可显着逆转东pol碱（维拉帕米治疗后即刻给药）引起的记忆巩固改善（1 mg / kg，腹膜内），但没有改变用无效剂量东pol碱（30 mg / kg）治疗的大鼠的被动回避反应。总之，目前的数据表明，1）维拉帕米的训练后给药可剂量依赖性地改善被动回避反应; 2）无效剂量的维拉帕米，取消了东pol碱的记忆巩固作用的改善; 3）存在相互作用胆碱能毒蕈碱受体与钙稳态相关机制在巩固情绪记忆中的作用。

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