首页> 外文期刊>Frontiers in Neuropharmacology >The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review
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The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review

机译:植物提取物和植物次生代谢产物对慢性神经炎症和认知衰老的免疫调节作用:机理和实证研究。

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Advances in healthcare have considerably improved the life expectancy of the human population over the last century and this has brought about new challenges. As we live longer the capacity for cognitive aging increases. Consequently, it has been noted that decline in cognitive performance in the elderly in domains of reasoning, problem solving skills, attention, processing speed, working memory and episodic memory is a significant societal problem. Despite the enormity of this issue there are relatively few interventions for cognitive ageing. This may be due to our current state of knowledge on biological factors that underpin cognitive ageing. One of the biological contributors to cognitive aging is chronic neuroinflammation. This review will provide an overview of the peripheral and central mechanisms involved in chronic neuroinflammation and how neuroinflammation may be related to age-associated cognitive decline. Plant based extracts including herbal and nutritional supplements with anti-inflammatory properties will be examined in relation to their utility in treating age-related cognitive decline. Plant based extracts in particular offer interesting pharmacological properties that may be quickly utilized to prevent cognitive ageing.
机译:在上个世纪,医疗保健的进步大大改善了人们的预期寿命,这带来了新的挑战。随着我们寿命的延长,认知衰老的能力增强。因此,已经注意到,老年人在推理,解决问题的能力,注意力,处理速度,工作记忆和情节记忆方面的认知能力下降是一个重要的社会问题。尽管这个问题非常严重,但认知衰老的干预措施相对较少。这可能是由于我们对支持认知老化的生物学因素的当前了解。认知衰老的生物学因素之一是慢性神经炎症。这篇综述将概述与慢性神经炎症有关的外周和中枢机制,以及神经炎症与年龄相关的认知能力下降如何相关。植物提取物(包括具有抗炎特性的草药和营养补品)将与它们在治疗与年龄有关的认知能力下降方面的效用进行检验。特别是基于植物的提取物提供了令人感兴趣的药理特性,可以迅速利用它们来防止认知老化。

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