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首页> 外文期刊>Frontiers in Neuropharmacology >Age and Sex Interact to Mediate the Effects of Intermittent, High-Dose Ethanol Exposure on Behavioral Flexibility
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Age and Sex Interact to Mediate the Effects of Intermittent, High-Dose Ethanol Exposure on Behavioral Flexibility

机译：年龄和性别相互作用介导间歇性大剂量乙醇暴露对行为灵活性的影响

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Human alcoholics have been shown to have impaired cognitive control over actions and increased reliance on habitual response strategies. While it is unclear in humans whether these differences predate ethanol exposure or result from chronic drinking, data from animal studies suggest that ethanol acts to promote the development of inflexible behaviors. Here, we investigated how intermittent exposure to high doses of ethanol impacts the ability to flexibly regulate behavior in a habit model. As adolescence may represent a period of increased drug taking and developmental vulnerability that may impact adult behavior, we compared the effects of high-dose ethanol exposure during adolescence to exposure during adulthood in male and female rats. Our findings indicated that the effects of intermittent, high-dose ethanol exposure on habitual behavior is mediated by age and sex such that ethanol exposure during adolescence promoted the use of habitual response strategies in adult females, but not males, and that the opposite pattern emerged following intermittent, high-dose ethanol exposure in adult rats.
机译：已证明人类酗酒者损害了对动作的认知控制，并增加了对习惯性反应策略的依赖。虽然尚不清楚这些差异是在乙醇暴露之前还是由长期饮酒引起的，但动物研究数据表明，乙醇起到促进僵硬行为发展的作用。在这里，我们研究了间歇性暴露于高剂量乙醇中如何影响习惯模型中行为的灵活调节能力。由于青春期可能代表一段时期内可能会影响成年行为的药物滥用和发育脆弱性增加，因此我们比较了雄性和雌性大鼠青春期大剂量乙醇暴露与成年期乙醇暴露的影响。我们的研究结果表明，间歇性，大剂量乙醇暴露对习惯行为的影响是由年龄和性别介导的，因此青春期乙醇暴露促进了成年女性而非男性的习惯性反应策略的使用，并且出现了相反的模式成年大鼠间歇性大剂量乙醇暴露后。

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