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首页> 外文期刊>Frontiers in Neurology >MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder
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MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder

机译：MOG-IgG相关的视神经炎，脑炎和脊髓炎：从神经脊髓炎视神经频谱疾病中学到的教训

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摘要

Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. MOG-IgG is associated with a wider clinical phenotype, not limited to NMOSD, with the majority of cases presenting with optic neuritis (ON), encephalitis with brain demyelinating lesions, and/or myelitis. Therefore, we propose the term MOG-IgG-associated Optic Neuritis, Encephalitis, and Myelitis (MONEM). Depending on the clinical characteristics, these patients may currently be diagnosed with NMOSD, acute disseminated encephalomyelitis, pediatric multiple sclerosis, transverse myelitis, or ON. With specific cell-based assays, MOG-IgG is emerging as a potential biomarker of inflammatory disorders of the central nervous system. We review the growing body of evidence on MONEM, focusing on its clinical aspects.
机译：在某些病例中发现了针对髓磷脂少突胶质细胞糖蛋白（MOG-IgG）的抗体，这些抗体被诊断为血清反应性神经脊髓炎视神经频谱疾病（NMOSD）。 MOG-IgG可以鉴定一个亚组，该亚组的临床过程不同于对Aquaporin-4-IgG抗体呈血清反应阳性的NMOSD患者。 MOG-IgG与更广泛的临床表型有关，不限于NMOSD，大多数病例表现为视神经炎（ON），伴有脑脱髓鞘病变的脑炎和/或脊髓炎。因此，我们提出与MOG-IgG相关的视神经炎，脑炎和脊髓炎（MONEM）。根据临床特征，这些患者目前可能被诊断出患有NMOSD，急性播散性脑脊髓炎，小儿多发性硬化症，横突性脊髓炎或ON。通过基于细胞的特定测定，MOG-IgG逐渐成为中枢神经系统炎症性疾病的潜在生物标记。我们回顾了有关MONEM的越来越多的证据，重点是其临床方面。

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