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首页> 外文期刊>Frontiers in Neurology >Computed Tomography Perfusion Alberta Stroke Program Early Computed Tomography Score Is Associated with Hemorrhagic Transformation after Acute Cardioembolic Stroke
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Computed Tomography Perfusion Alberta Stroke Program Early Computed Tomography Score Is Associated with Hemorrhagic Transformation after Acute Cardioembolic Stroke

机译：计算机断层扫描灌注阿尔伯塔省卒中计划早期的计算机断层扫描评分与急性心脏栓塞性卒中后的出血性转化有关

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Alberta Stroke Program Early Computed Tomography (CT) score (ASPECTS) has been applied to CT perfusion (CTP) with good interrater agreement to predict early ischemic stroke, and it can be useful in decision making in acute ischemic stroke. The aim of the present study was to assess the predictive value of CTP ASPECTS of hemorrhagic transformation (HT) in acute cardioembolic stroke. This is a single-enter, retrospective study. All patients hospitalized with acute cardioembolic stroke from January 2008 to September 2013 were included. ASPECTS of baseline non-contrast CT, CTP maps of cerebral blood volume (CBV), cerebral blood flow, and mean transit time were collected from 52 consecutive patients with less than 12-h anterior circulation ischemic stroke. MRI scan was performed within 72?h of symptom onset after index stroke including T2*-weighted gradient echo to identify HT. For bleeding risk assessment, CTP and diffusion-weighted imaging ASPECTS were categorized into 0–7 or 8–10. Baseline characteristics, ASPCETS scores and HT were compared. Eighteen (34.6%) patients had HT and four (7.7%) developed symptomatic HT. On univariate analysis, the proportion of patients with CBV-ASPECTS 0–7 was significantly higher in HT patients as compared to patients without HT (44 versus 9%, P ?=?0.005). CBV ASPECTS 0–7 remained independent prognostic factors for HT after adjustment for clinical baseline variables. CBV ASPECTS could be of value to predict HT risk after acute cardioembolic stroke and may be a quick risk assessment approach before reperfusion therapy.
机译：艾伯塔省卒中计划早期计算机断层扫描（CT）评分（ASPECTS）已应用于具有良好的间质一致性的CT灌注（CTP）来预测早期缺血性卒中，它可用于急性缺血性卒中的决策。本研究的目的是评估出血性转化（HT）的CTP ASPECTS对急性心脏栓塞性中风的预测价值。这是一项单项回顾性研究。纳入了2008年1月至2013年9月住院的急性心脏栓塞性中风的所有患者。从52例前循环缺血性卒中少于12小时的连续患者中收集基线非造影CT的ASPECTS，脑血容量（CBV）的CTP图，脑血流量和平均通过时间。指数卒中后症状发作后72小时内进行MRI扫描，包括T2 *加权梯度回波以确定HT。对于出血风险评估，CTP和弥散加权成像ASPECTS分为0-7或8-10。比较基线特征，ASPCETS得分和HT。十八名（34.6％）患有HT，四名（7.7％）出现症状性HT。单因素分析显示，HT患者中CBV-ASPECTS 0-7患者的比例明显高于非HT患者（44％对9％，P = 0.005）。调整临床基线变量后，CBV ASPECTS 0-7仍然是HT的独立预后因素。 CBV ASPECTS可能对预测急性心脏栓塞性中风后的HT风险具有价值，并且可能是再灌注治疗前的快速风险评估方法。

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