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首页> 外文期刊>Frontiers in Pharmacology >Yi Shen Juan Bi Pill Ameliorates Bone Loss and Destruction Induced by Arthritis Through Modulating the Balance of Cytokines Released by Different Subpopulations of T Cells
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Yi Shen Juan Bi Pill Ameliorates Bone Loss and Destruction Induced by Arthritis Through Modulating the Balance of Cytokines Released by Different Subpopulations of T Cells

机译：益肾卷痹丸通过调节T细胞不同亚群释放的细胞因子平衡，减轻关节炎引起的骨质流失和破坏。

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The Yi Shen Juan Bi Pill (YSJB), a traditional Chinese compound herbal drug, has been used as an anti-rheumatic drug in clinical practice. Cartilage and bone destruction of inflamed joints is the hallmark of rheumatoid arthritis (RA). Our previous study suggested that YSJB had a protective effect on joint damage in collagen-induced (CIA) rats. However, the role and the mechanism of YSJB in inflammation-induced bone loss are unavailable. The current study aimed to further evaluate the effect of YSJB on the joint destruction and the systemic bone loss, and to clarify the potential mechanism. CIA model was generated by using collagen II and incomplete Freund's adjuvant in Sprague-Dawley rats. After 4 weeks treatment, arthritic index, tissue pathology, micro-computed tomography scanning (μ-CT), and bone mineral density (BMD) analysis were performed. YSJB decreased arthritic scores and bone destruction; improved the BMD of lumbar vertebrae and bone volume fraction of inflamed joints. Moreover, YSJB significantly decreased the production of serum bone resorption markers, including Tartrate-Resistant Acid Phosphatase (TRACP), N-terminal telopeptide of type I collagen and C-terminal telopeptide of type I collagen. Meanwhile, it increased the level of serum bone formation marker type I collagen N-terminal propeptide. These results revealed that YSJB ameliorated bone destruction and reduced bone loss induced by arthritis. We have previously showed that Tregs inhibited osteoclast differentiation and bone resorption in vitro . Furthermore, others suggested that abnormality of Th1, Th17 may contribute to bone destruction. Here, we showed YSJB significantly up-regulated the percentage of Tregs, while also down-regulated the percentage of Th1 and Th17 cells. Our findings provide the evidence that YSJB ameliorates the severity of disease and joint degradation, and reduces systemic bone loss induced by arthritis. We propose YSJB modulates the balance of T cell phenotype, which affects the activation and differentiation of osteoclasts.
机译：传统的中草药复方益肾娟痹丸（YSJB）在临床实践中已被用作抗风湿药。关节炎症的软骨和骨质破坏是类风湿关节炎（RA）的标志。我们先前的研究表明，YSJB对胶原诱导（CIA）大鼠的关节损伤具有保护作用。然而，YSJB在炎症诱导的骨丢失中的作用和机制尚不可用。当前的研究旨在进一步评估YSJB对关节破坏和全身性骨丢失的影响，并阐明其潜在机制。通过使用胶原蛋白II和弗氏不完全佐剂在Sprague-Dawley大鼠中建立CIA模型。治疗4周后，进行了关节炎指数，组织病理学，显微计算机断层扫描（μ-CT）和骨矿物质密度（BMD）分析。 YSJB降低了关节炎评分和骨骼破坏;改善了腰椎的骨密度和发炎关节的骨体积分数。此外，YSJB显着降低了血清骨吸收标记物的产生，包括抗酒石酸酸性磷酸酶（TRACP），I型胶原蛋白的N端端肽和I型胶原蛋白的C端端肽。同时，它增加了血清骨形成标记物I型胶原蛋白N末端前肽的水平。这些结果表明，YSJB改善了骨质破坏并减少了由关节炎引起的骨质流失。我们以前曾表明，Tregs在体外抑制破骨细胞分化和骨吸收。此外，其他人认为Th1，Th17异常可能导致骨破坏。在这里，我们显示YSJB显着上调了Tregs的百分比，同时还下调了Th1和Th17细胞的百分比。我们的发现提供了证据，表明YSJB改善了疾病和关节退化的严重性，并减少了由关节炎引起的全身性骨丢失。我们提出YSJB调节T细胞表型的平衡，这影响破骨细胞的活化和分化。

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