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首页> 外文期刊>Frontiers in Oncology >Glycosylation in Cancer: Interplay between Multidrug Resistance and Epithelial-to-Mesenchymal Transition?
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Glycosylation in Cancer: Interplay between Multidrug Resistance and Epithelial-to-Mesenchymal Transition?

机译：癌症中的糖基化：多药耐药性与上皮间质转化之间的相互作用？

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摘要

The expression of unusual glycan structures is a hallmark of cancer progression, and their functional roles in cancer biology have been extensively investigated in epithelial-to-mesenchymal transition (EMT) models. EMT is a physiological process involved in embryonic development and wound healing. It is characterized by loss of epithelial cell polarity and cell adhesion, permitting cell migration, and thus formation of new epithelia. However, this process is unwanted when occurring outside their physiological limit, resulting in fibrosis of organs and progression of cancer and metastasis. Several studies observed that EMT is related to the acquisition of multidrug resistance (MDR) phenotype, a condition in which cancer cells acquire resistance to multiple different drugs, which has virtually nothing in common. However, although some studies suggested interplay between these two apparently distinct phenomena, almost nothing is known about this possible relationship. A common pathway to them is the need for glycosylation, a post-translational modification that can alter biological function. Thus, this review intends to compile the main facts obtained until now in these two areas, as an effort to unravel the relationship between EMT and MDR.
机译：不寻常的聚糖结构的表达是癌症进展的标志，并且已经在上皮-间充质转化（EMT）模型中广泛研究了它们在癌症生物学中的功能。 EMT是涉及胚胎发育和伤口愈合的生理过程。其特征在于上皮细胞极性和细胞粘附性的丧失，允许细胞迁移，从而形成新的上皮细胞。但是，在超出其生理极限时会发生此过程，从而导致器官纤维化以及癌症和转移的进展。几项研究发现，EMT与多药耐药性（MDR）表型的获得有关，在这种情况下，癌细胞对多种不同药物具有耐药性，这实际上没有什么共同之处。但是，尽管一些研究表明这两种明显不同的现象之间存在相互作用，但对于这种可能的关系几乎一无所知。到达它们的常见途径是需要糖基化，这是一种可以改变生物学功能的翻译后修饰。因此，本综述旨在汇编迄今为止在这两个领域中获得的主要事实，以期揭示EMT与MDR之间的关系。

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