...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Oncology >Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications
【24h】

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

机译：尿激酶型纤溶酶原激活物（uPA）及其受体（uPAR）的多方面作用：诊断，预后和治疗应用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes. A large body of evidence support that among the various components of the PA system, urokinase-type plasminogen activator (uPA), its receptor (uPAR), and plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) play a major role in tumor progression and metastasis. The binding of uPA with uPAR is instrumental for the activation of plasminogen to plasmin, which in turn initiates a series of proteolytic cascade to degrade the components of the extracellular matrix, and thereby, cause tumor cell migration from the primary site of origin to a distant secondary organ. The components of the PA system show altered expression patterns in several common malignancies, which have identified them as ideal diagnostic, prognostic, and therapeutic targets to reduce cancer-associated morbidity and mortality. This review summarizes the various components of the PA system and focuses on the role of uPA–uPAR in different biological processes especially in the context of malignancy. We also discuss the current state of knowledge of uPA–uPAR-targeted diagnostic and therapeutic strategies for various malignancies.
机译：纤溶酶原激活剂（PA）系统是一种与各种生理和病理生理过程相关的细胞外蛋白水解酶系统。大量证据支持在PA系统的各个组成部分中，尿激酶型纤溶酶原激活物（uPA），其受体（uPAR）以及纤溶酶原激活物抑制剂1和-2（PAI-1和PAI-2）发挥作用在肿瘤进展和转移中起重要作用。 uPA与uPAR的结合有助于纤溶酶原活化为纤溶酶，进而引发一系列蛋白水解级联反应，降解细胞外基质的成分，从而导致肿瘤细胞从原发部位向远处迁移次要器官。 PA系统的组件在几种常见的恶性肿瘤中表现出改变的表达模式，已将它们确定为降低癌症相关发病率和死亡率的理想诊断，预后和治疗靶标。这篇综述总结了PA系统的各个组成部分，并着重介绍了uPA–uPAR在不同生物学过程中的作用，尤其是在恶性肿瘤中。我们还将讨论针对各种恶性肿瘤的uPA–uPAR靶向诊断和治疗策略的当前知识状态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号