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An IR navigation system for pleural PDT

机译：胸膜PDT的红外导航系统

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Pleural photodynamic therapy (PDT) has been used as an adjuvant treatment with lung-sparing surgical treatment for malignant pleural mesothelioma (MPM). In the current pleural PDT protocol, a moving fiber-based point source is used to deliver the light. The light fluences at multiple locations are monitored by several isotropic detectors placed in the pleural cavity. To improve the delivery of light fluence uniformity, an infrared (IR) navigation system is used to track the motion of the light source in real-time at a rate of 20 - 60 Hz. A treatment planning system uses the laser source positions obtained from the IR camera to calculate light fluence distribution to monitor the light dose uniformity on the surface of the pleural cavity. A novel reconstruction algorithm is used to determine the pleural cavity surface contour. A dual-correction method is used to match the calculated fluences at detector locations to the detector readings. Preliminary data from a phantom shows superior light uniformity using this method. Light fluence uniformity from patient treatments is also shown with and without the correction method.
机译：胸膜光动力疗法（PDT）已被用作辅助治疗肺保留性间皮瘤（MPM）的保肺手术。在当前的胸膜PDT协议中，基于移动光纤的点光源用于传递光。多个位置的光通量通过放置在胸膜腔中的几个各向同性探测器进行监控。为了提高光通量均匀性的传递，使用红外（IR）导航系统以20-60 Hz的速率实时跟踪光源的运动。治疗计划系统使用从红外摄像机获得的激光源位置来计算光通量分布，以监视胸膜腔表面上的光剂量均匀性。一种新颖的重建算法用于确定胸膜腔表面轮廓。使用双重校正方法将检测器位置处的计算通量与检测器读数进行匹配。使用该方法，来自幻像的初步数据显示出优异的光均匀性。还显示了使用和不使用校正方法时来自患者治疗的光通量均匀性。

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