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Fragmentation Behavior Studies of Chalcones Employing Direct Analysis in Real Time (DART)

机译：实时直接分析（DART）的Chalcones碎片行为研究

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Chalcones are naturally occurring, biologically active molecules generating interest from a wide range of research applications including synthetic methodology development, biological activity investigation and studying fragmentation patterns. In this article, a series of chalcones has been synthesized and their fragmentation behavior was studied using modern ambient ionization technique Direct Analysis in Real Time (DART). DART ion source connected with an ion trap mass spectrometer was used for the fragmentation of various substituted chalcones. The chalcones were introduced to the DART source using a glass capillary without sample preparation step. All the chalcones showed prominent molecular ion peaks corresponding to the structures. Multistage mass spectral data ( and ) were collected for all the chalcones studied. The chalcones with substitutions at 3, 4 or 5 positions gave product ion peaks with the loss of a phenyl radical ( ) by radical initiated -cleavage, while substitution at 2 position of chalcone in the A-ring gave a product ion peak with the loss of substituted styryl radical (PhCH.
机译：查耳酮是天然存在的生物活性分子，在广泛的研究应用中引起了人们的兴趣，包括合成方法学开发，生物活性研究和研究片段化模式。在本文中，合成了一系列查耳酮，并使用现代环境电离技术实时直接分析（DART）研究了它们的碎片行为。与离子阱质谱仪连接的DART离子源用于各种取代的查耳酮的裂解。使用玻璃毛细管将查耳酮引入DART源，而无需样品制备步骤。所有查耳酮均显示出与结构相对应的突出分子离子峰。收集了所有研究的查耳酮的多级质谱数据（和）。在3、4或5个位置被取代的查耳酮通过自由基引发的裂解产生了一个产物离子峰，并带有一个苯基自由基（）丢失，而在A环中的查耳酮的2个位置被取代给出了一个具有损失的产物离子峰。取代的苯乙烯基自由基（PhCH。

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