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首页> 外文期刊>Mass Spectrometry Letters >Determination of S- and R-Amlodipine in Rat Plasma using LC-MS/MS After Oral Administration of S-Amlodipine and Racemic Amlodipine
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Determination of S- and R-Amlodipine in Rat Plasma using LC-MS/MS After Oral Administration of S-Amlodipine and Racemic Amlodipine

机译：口服S-氨氯地平和消旋氨氯地平后，使用LC-MS / MS测定大鼠血浆中的S-和R-氨氯地平

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摘要

The pharmacokinetic properties of S-amlodipine were studied using racemic amlodipine and single S-enantiomer (SK310) administration to rats. Plasma levels of the drug were determined using chiral liquid chromatography coupled with tandem mass spectrometry following solid phase extraction. The stereospecific analysis of amlodipine was performed on an -acid glycoprotein (AGP) column using a mobile phase comprising 10 mM ammonium acetate (pH 4.0) and propanol at a flow rate of 0.2 mL/min. This method was used to perform a comparative study of the pharmacokinetics of amlodipine and SK310. The results revealed that the pharmacokinetic profile of S-amlodipine after the administration of SK310 was comparable to that following the administration of the racemic mixture.
机译：研究了外消旋氨氯地平和单一S-对映体（SK310）对大鼠的S-氨氯地平的药代动力学特性。固相萃取后，使用手性液相色谱和串联质谱法测定药物的血浆水平。氨氯地平的立体定向分析是在酸性糖蛋白（AGP）色谱柱上进行的，使用的流动相为0.2 mL / min的乙酸铵（pH 4.0）和丙醇。该方法用于对氨氯地平和SK310的药代动力学进行比较研究。结果表明，施用SK310后，S-氨氯地平的药代动力学特征与施用外消旋混合物后的药代动力学特征相当。

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