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首页> 外文期刊>Materials >Biological Evaluation of Flexible Polyurethane/Poly l -Lactic Acid Composite Scaffold as a Potential Filler for Bone Regeneration
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Biological Evaluation of Flexible Polyurethane/Poly l -Lactic Acid Composite Scaffold as a Potential Filler for Bone Regeneration

机译：柔性聚氨酯/聚乳酸-乳酸复合支架作为骨再生潜在填充物的生物学评估

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Degradable bone graft substitute for large-volume bone defects is a continuously developing field in orthopedics. With the advance in biomaterial in past decades, a wide range of new materials has been investigated for their potential in this application. When compared to common biopolymers within the field such as PLA or PCL, elastomers such as polyurethane offer some unique advantages in terms of flexibility. In cases of bone defect treatments, a flexible soft filler can help to establish an intimate contact with surrounding bones to provide a stable bone-material interface for cell proliferation and ingrowth of tissue. In this study, a porous filler based on segmented polyurethane incorporated with poly l -lactic acid was synthesized by a phase inverse salt leaching method. The filler was put through in vitro and in vivo tests to evaluate its potential in acting as a bone graft substitute for critical-sized bone defects. In vitro results indicated there was a major improvement in biological response, including cell attachment, proliferation and alkaline phosphatase expression for osteoblast-like cells when seeded on the composite material compared to unmodified polyurethane. In vivo evaluation on a critical-sized defect model of New Zealand White (NZW) rabbit indicated there was bone ingrowth along the defect area with the introduction of the new filler. A tight interface formed between bone and filler, with osteogenic cells proliferating on the surface. The result suggested polyurethane/poly l -lactic acid composite is a material with the potential to act as a bone graft substitute for orthopedics application.
机译：可降解的骨移植物替代大体积骨缺损是骨科领域一个不断发展的领域。随着过去几十年来生物材料的发展，已经研究了各种各样的新材料在这种应用中的潜力。与本领域中的常见生物聚合物（例如PLA或PCL）相比，弹性体（例如聚氨酯）在柔韧性方面提供了一些独特的优势。在进行骨缺损治疗的情况下，柔性软填充物可帮助与周围骨骼建立紧密接触，从而为细胞增殖和组织向内生长提供稳定的骨骼-材料界面。在这项研究中，通过反相盐浸法合成了基于嵌段聚氨酯和聚乳酸的多孔填料。对该填充物进行了体外和体内测试，以评估其在替代临界尺寸骨缺损中用作骨移植替代物的潜力。体外结果表明，与未经修饰的聚氨酯相比，当播种在复合材料上时，成骨细胞样细胞的生物学反应（包括细胞附着，增殖和碱性磷酸酶表达）有了重大改善。对新西兰白兔（NZW）的临界尺寸缺陷模型进行的体内评估表明，随着新填充剂的引入，沿缺陷区域有骨向内生长。骨与填充物之间形成紧密的界面，成骨细胞在表面增殖。结果表明，聚氨酯/聚乳酸复合物是一种有潜力用作骨科应用的骨移植替代物的材料。

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